L-tyrosine, B6 and folic acid are involved in biosynthesis of DOPA and consequently dopamine. The aim of this study was to investigate the antiparkinsonian effect of these agents in perphenazine-induced catatonia in rats. Murprogo method or scored muscular rigidity, which is induced by a phenothiazine, was used to evaluate the antiparkinsonian effect of these agents. A significant decrease in m...

Muscular dystrophies are a genetically heterogeneous group of degenerative muscle disorders. It characterized by progressive muscle wasting and weakness of variable distribution and severity. There are several subgroups including Duchenne/Becker, fascioscapulohumeral, limb-girdle, oculopharngeal, and congenital muscular dystrophy. Diagnosis is dependent to the characteristic clinical features i...

Hereditary spinal muscular atrophy is a motor neuron disorder characterized by muscle weakness and atrophy due to degeneration of the anterior horn cells of the spinal cord. Initially, the disease was considered purely as an autosomal recessive condition caused by loss-of-function SMN1 mutations on 5q13. Recent developments in next generation sequencing technologies, however, have unveiled a gr...

The objective of the present work is to investigate prospective associations between physical fitness components (cardiorespiratory fitness, motor and muscular strength) two domains executive function (working memory inhibitory control) in adolescents. A total 422 Spanish adolescents (13.35 ± 1.54 years, at baseline) from UP&DOWN study with assessments baseline 2-year follow-up were included an...

Deflazacort is the most commonly prescribed corticosteroid for the treatment of Duchenne muscular dystrophy in Canada. We review the long-term experience with deflazacort treatment at two centers in Canada; Montreal and Toronto. Deflazacort has benefitted both cohorts by prolonged ambulation, preserved cardiac and respiratory function, less scoliosis and improved survival. Common side effects i...

[Purpose] It is well known that visual feedback is an important factor contributing to balance and postural control. Nevertheless, there has been little discussion about the effects of visual feedback on pulmonary function. This study was conducted to investigate the role of visual feedback on respiratory muscle activation and pulmonary function. [Subjects and Methods] The subjects were 37 heal...

Central and Reflex Changes of Muscle Function Muscular Imbalance Muscular imbalance and Its Nature The Development of Muscle Function in Light of Postural Ontogenesis Postural Ontogenesis—Motor Programs The Development of Functional Joint Centration The Neonatal Stage The Suprapubic Reflex Support Reaction Automatic Gait The Crossed Extension Reflex Calcaneal (Heel) Reflex The Fourth Through Si...