Voltage-gated sodium channels are targets for many drugs and toxins. However, the rational design of medically relevant channel modulators is hampered by the lack of x-ray structures of eukaryotic channels. Here, we used a homology model based on the x-ray structure of the NavAb prokaryotic sodium channel together with published experimental data to analyze interactions of the μ-conotoxins GIII...

Voltage-gated sodium (Nav) channels are important targets in the treatment of a range of pathologies. Bacterial channels, for which crystal structures have been solved, exhibit modulation by local anesthetic and anti-epileptic agents, allowing molecular-level investigations into sodium channel-drug interactions. These structures reveal no basis for the "hinged lid"-based fast inactivation, seen...

BACKGROUND & OBJECTIVES The mechanism of antimony resistance in Leishmania has been studied extensively, in connection with decreased influx and/or increased eflux of the drug. Aquaporin 1 (AQP1) protein has been shown to mediate the uptake of trivalent antimony. This study was aimed to find the expression level of AQP1 gene in resistant versus non-resistant clinical isolates of Leishmania majo...

We present new Brownian dynamics techniques for studying blockers of ion channels. By treating the channel as a fixed body, simulating the blocker molecules using rigid bodies, and using an implicit water force field with explicit ions, we are able to carry out fast simulations that can be used to investigate the dynamics of block and unblock, deduce binding modes, and calculate binding affinit...

background & aim: in recent years, iran and other countries pay special attention to side effects of chemical plants. this interest in plants and their derivatives leads to business of medicinal plants. in caspian region, in forestry projects there are many plant species with medicinal uses from which the locale indigenous used due to traditional experience without any especial processing i...

abstract investigating economic advantages of people participation in irrigation and drainage network development in fourth area of band-e-amir region was the objective of this study. that area is 3950 hectares. case study was the research method. those farmers who participated and benefited of the project and experts and executors of the project were statistical society of this study. findings...

Risk management is one of the most influential parts of project management that has a major impact on the success or failure of projects. Due to the increasing use of information technology (IT) systems in all fields and the high failure rate of IT projects in software development and production, it is essential to effectively manage these projects is essential. Therefore, this study is aimed t...

Critical Success Factors (CSFs) are used to support and evaluate the success of a strategic and tactical approach in project implementation in order to increase the probability of success. This system is used by executors in project delivery to achieve improved performance capabilities with limited resources. The present paper aims to identify the impact of CSFs amongst the main elements involv...

the economic and social impact of public participation in hableh roud project has been assessed in the current study. this is a practical-operational research implemented as based upon descriptive method. the study population included 187 individual residents in 8 villages within the hableh roud catchment basin in tehran province. random sampling was utilized and the recommendations of experts ...

Project management is an important factor to accomplish the decision to implement large-scale software systems (LSS) in a successful manner. The effective project management comes into play to plan, coordinate and control such a complex project. Project management factor has been argued as one of the important Critical Success Factor (CSF), which need to be measured and monitored carefully duri...