Although it has been proposed that the beneficial effect of HER2-targeted therapy in HER2-negative breast cancer is associated with the molecular subtype conversion, the underlying mechanism and the clinical biomarkers are unclear. Our study showed that breast cancer stem cells (BCSCs) mediated HER2 subtype conversion and radioresistance in HER2-negative breast cancer cells and evaluated serum ...

background: we studied the patterns of premenopausal and postmenopausal breast cancer incidence and its established risk factors in iran in 2010. in addition, we estimated the 5-year prevalence of breast cancer in the country. methods: we performed an internet and library literature review. we used national cancer registry data, demographic health surveys, national censuses and world bank data ...

Introduction: Breast cancer is one of the most common types of cancer in women with an increasing outbreak. The present study aimed to investigate the relationship between defensive styles and Islamic quality of life (QoL) with death obsession in women with breast cancer. Methods: This research was a correlational study. The statistical population of the study included 220 female patients with...

breast cancer is the most common cancer occurring among women. the mortality rate of breast cancer can be reduced by regular breast cancer screening program. this study was carried out to identify the knowledge and practice of women about breast cancer screening in zahedan, southeast of iran. in this cross- sectional study, 384 women were selected as an improbability sample of women referring t...

background: breast cancer is the most common malignancy in women. breast cancer type 1 susceptibility gene (brca1) is a tumor suppressor gene, involved in dna damage repair and in 81% of the breast-ovarian cancer families were due to brca1. in some clinically investigated genes, the intragenic marker polymorphism is important and the screening of such mutations is faster by using short tandem r...

It has long been accepted that modern reproductive patterns are likely contributors to breast cancer susceptibility because of their influence on hormones such as estrogen and the importance of these hormones in breast cancer. We conducted a meta-analysis to assess whether this 'evolutionary mismatch hypothesis' can explain susceptibility to both estrogen receptor positive (ER-positive) and est...

background: breast cancer incidence has increased rapidly inkuwait, but there haven’t been any studies investigating the recognized risk factors of breast cancer inkuwait. the aim of the study was to investigate breast cancer risk factors among women inkuwait.   methods: a case-control study was conducted in kuwait from may 2003 to march 2004 using a questionnaire including socio-demographic da...