The constancy of action potential conduction in the central nervous system (CNS) relies on uniform axon diameter coupled with fidelity of the overlying myelin providing high-resistance, low capacitance insulation. Whereas the effects of demyelination on conduction have been extensively studied/modeled, equivalent studies on the repercussions for conduction of axon swelling, a common early patho...

objectives to compare an out-of-plane interscalene catheter technique to the in-plane technique in a randomized clinical trial. patients and methods eighty-four patients undergoing open shoulder surgery were randomized to either the in-plane or out-of-plane ultrasound-guided continuous interscalene technique. the primary outcome was vas pain rating at 24 hours. secondary outcomes included pain ...

the biological effects of omega-3 and omega-6 fatty acids are determined by their mutual interactions. this interaction extremely affects various functions. lower consumption of omega-3 during gestation leads to various disorders, even in hearing. we aimed to assess the effect of low omega-3/omega-6 ratios on auditory nerve conduction. in this experimental study, the auditory brainstem response...

Anti-ganglioside (anti-GM1) antibodies have been implicated in the pathogenesis of Guillain-Barré syndrome, multifocal motor neuropathy and motor neuron diseases. It has been held that they may interfere with saltatory conduction by blocking sodium channels. We tested this hypothesis by analysing action potentials from 140 single nerve fibres in 22 rat ventral roots using external longitudinal ...

Direct percutaneous stimulation of the proximal sciatic nerve with a high voltage electrical stimulator was given to a patient with acute sciatic compression neuropathy. Results clearly showed a focal conduction block at the sciatic notch, which could not be precisely localised and quantified by conventional electrodiagnostic methods.

Neurophysiology studies in a 50-year-old man with slowly progressive weakness of the left upper limb revealed conduction block in the ulnar nerve above the elbow. His weakness remained stable with regular subcutaneous immunoglobulin, but he noted gradual hemibody hair depigmentation. Examination also revealed unilateral left hand leukonychia (figure). MRI of the brain and cervical spine was nor...

Local compression is known to damage peripheral nerves. Severe compression may actually crush the fibres and lead to Wallerian degeneration; the excitability of the nerve distal to the lesion is lost and recovery may take many months (Seddon, 1943; Denny-Brown & Brenner, 1944 a). Mild compression produces a physiological block which is reversed as soon as the pressure is released. On the basis ...

OBJECTIVE A method for conduction block (CB) estimation, based on compound muscle action potentials (CMAP) elicited by stimulation at sites proximal and distal to the region in which a block is suspected, which is less sensitive to temporal dispersion than methods based on area and amplitude estimation, routinely used in clinical practice. METHODS The method is based on deconvolution of CMAPs...