The approach to airway management in the multiple trauma patient has changed significantly over the past decade. A number of central controversies have been identified, and the debates continue. This article identifies the major controversies in trauma airway management, reviews and summarizes relevant literature, and presents specific recommendations and supporting arguments. Particular emphas...

the potential changes in neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. org-9426 (rocuronium) and org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. the problems seen after prolonged administration of muscle relaxants are thought to arise fr...

The interactions between tubocurarine, pancuronium and alcuronium on neuromuscular transmission have been studied in an isolated neuromuscular preparation (the rat phrenic nerve-hemidiaphragm). Mixtures of tubocurarine and pancuronium, and tubocurarine and alcuronium were found to have a more potent effect than the additive effects of the individual agents when given alone, that is, mixtures we...

We describe a sero-negative ocular myasthenic patient who showed exaggerated responses to both vecuronium and neostigmine. These hypersensitive responses were not anticipated because preoperative clinical and laboratory evaluations suggested a negligible impairment of somatic muscles by myasthenic processes. This case report re-emphasizes that, if neuromuscular blocking agents and their antagon...

Postpolio syndrome is a disorder related to the recurrence of neuromuscular symptoms in survivors of paralytic poliomyelitis. A comprehensive understanding of the pathophysiology is necessary for the anesthesia provider to develop a safe anesthetic plan. This case report discusses the anesthetic challenges and considerations in patients with postpolio syndrome, focusing on the importance of car...

BACKGROUND To avoid postoperative residual neuromuscular block there is a need for a change in clinician's attitude towards monitoring and reversal. This study aims to evaluate changes of perioperative neuromuscular block management during the last decade in our institution and to quantify the incidence of postoperative residual neuromuscular block. METHODS Patients receiving intermediate-act...

Background: Neuromuscular blockers (NMB) are very important for generalanesthesia, Rocuronium and Vecuronium are used as non-depolarizing muscle relaxants. In a randomized study we had compared both drugs as regard theonset of action, intubating condition and hemodynamic changes. Method:-Sixty patients ( 20 to 60 year), scheduled to undergo elective general surgery, were included in thisrandomi...

The potential changes In neuromuscular blockade after chronic (>24 h) administration of sub-paralytic doses of two newly introduced aminosteroidal muscle relaxants were investigated. Org-9426 (rocuronium) and Org-9487 were studied in the in vivo guinea pig gastrocnemius muscle-sciatic nerve preparation. The problems seen after prolonged administration of muscle relaxants are thought to ari...