The mTORC1 nutrient-sensing pathway integrates metabolic and endocrine signals into the brain to evoke physiological responses food deprivation, such as autophagy. Nevertheless, impact of neuronal activity on circuits organismal metabolism remains obscure. Here, we show that inhibition acutely perturbs serotonergic neurotransmission via proteostatic alterations evoked by autophagy inducer atg1....

The neuronal synapse is comprised of several distinct zones, including presynaptic vesicle zone (SVZ), active zone (AZ) and postsynaptic density (PSD). While correct relative positioning of these zones is believed to be essential for synaptic function, the mechanisms controlling their mutual localization remain unexplored. Here, we employ high-throughput quantitative confocal imaging, super-res...

Fine-tuning of neuronal activity was thought to be a neuron-autonomous mechanism until the discovery that astrocytes are active players of synaptic transmission. The involvement of astrocytes has changed our understanding of the roles of non-neuronal cells and shed new light on the regulation of neuronal activity. Microglial cells are the macrophages of the brain and they have been mostly inves...

We propose and investigate two information-based measures of statistical dispersion of neuronal firing: the entropy-based dispersion and Fisher information-based dispersion. The measures are compared with the standard deviation. Although the standard deviation is used routinely, we show, that it is not well suited to quantify some aspects of dispersion that are often expected intuitively, such ...

The accuracy of neuronal encoding depends on the response statistics of individual neurons and the correlation of the activity between different neurons. Here, the dynamics of the neuronal response statistics in the anterior superior temporal sulcus of the macaque monkey is described. A transient reduction in the normalized trial-by-trial variability and decorrelation of the responses with both...

We investigate the optimal control of neuronal spiking activity for neurons receiving a class of random synaptic inputs, characterized by a positive parameter alpha. Optimal control signals and optimal variances are found exactly for the diffusion process approximating an integrate and fire model. When synaptic inputs are "sub-Poisson" (alpha<0.5), we find that the optimal synaptic input is a d...

A telemetric system is described which allows the wireless registration of extracellular neuronal activity and vocalization-associated skull vibrations in freely moving, socially living squirrel monkeys (Saimiri sciureus). The system consists of a carrier platform with numerous guiding tubes implanted on the skull. Custom-made microdrives are mounted on the platform, allowing the exploration of...

Patients with limbic encephalitis usually present with new onset mesial temporal lobe seizures, progressive memory disturbance, and a variety of other behavioral, emotional, and cognitive changes. Autoimmune inflammation of the limbic gray matter structures of the human brain has recently been identified as major cause of mesial temporal lobe epilepsy with interictal temporal epileptiform activ...

due to the worldwide increase in the number of older people in both developed and developing countries, there is a public health concern for dealing with age related diseases such as neurodegenerative diseases. there is little known about the difference in neuronal cell responses between genders. our understanding of the neuronal cell response regarding genders, will be useful for developing mo...