The enzymes responsible for the degradation of nitrofuran derivatives in rat small intestinal mucosa were examined in vitro.As a result,it was suggested that the initial reactions in the degradation of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide(AF-2) and 5-nitro-2-furfural semicarbazone(nitrofurazone)are mainly catalyzed by xanthine oxidase , while that of 2-amino-5-[2-(5-nitro-2-fury1)-1-(2-fur...

The in vitro activities of 39 antimicrobial agents against 23 isolates of Treponema hyodysenteriae, the majority of which were field isolates, were determined by the agar dilution technique. Quinoxalines, pleuromutilin, nitroimidazoles, and nitrofuran were the most active. Their activities ranged from </=0.10 to 1.56 mug/ml. Lincomycin, penicillins, chloramphenicol, tetracyclines, cephalosporin...