نتایج جستجو برای: nitrofuran

تعداد نتایج: 336  

2012
Linna Zhou Hironori Ishizaki Michaela Spitzer Kerrie L. Taylor Nicholas D. Temperley Stephen L. Johnson Paul Brear Philippe Gautier Zhiqiang Zeng Amy Mitchell Vikram Narayan Ewan M. McNeil David W. Melton Terry K. Smith Mike Tyers Nicholas J. Westwood E. Elizabeth Patton

Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of prodrugs widely used to treat bacterial and trypanosome infections, but despite relative specificity, 5-nitrofurans often cause serious toxic side effects in people. Here, we use yeast and zebrafish, as well as human in vitro systems, to as...

2012
REVATHI A. GUPTA SATISH G. KASKHEDIKAR

A series of novel N'-((5-nitrofuran-2-yl/4-nitrophenyl) methylene) substituted hydrazides (3a-3i & 4a-4i) was synthesized, and tested for in vitro antimycobacterial activity, and their quantitative structure activity relationship (QSAR) of hydrazide derivatives is reported here. The results of anti-mycobacterial activity study indicated that the presence of halogen substitution at benzohydrazid...

2017
Alireza Foroumadi Hadi Adibi Sussan Kabudanian Ardestani Samira Shirooie Arezoo Bozorgomid Ali Jafari

A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a-6e have been synthesized and screened for in-vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

Journal: :Cancer research 1969
J E Morris J M Price J J Lalich R J Stein

Three 5-nitrofuran derivatives showed carcinogenic activity when fed to female Holtzman rats at levels of 0.1 to 0.3% in a commercial diet for up to 44.5 weeks, while 2 other 5-nitrofuran derivatives and 5,5-diphenylhydantoin were inactive. Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]hydrazide induced benign and malignant tumors of the mammary glands, adenomas or adenocarcinomas of the kidne...

2014
Rakesh David F. Bruhn Michael S. Scherman Lisa K. Woolhiser Dora B. Madhura Marcus M. Maddox Aman P. Singh Robin B. Lee Julian G. Hurdle Michael R. McNeil Anne J. Lenaerts Bernd Meibohm Richard E. Lee

The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB bacilli. In previous studies, the pharmacokinetic properties of nitrofuranyl isoxazolines were improved by incorporation of the outer ring elements of ...

Journal: :Journal of clinical microbiology 1976
J C Curry G E Borovian

A nitrofuran-containing medium, FTO agar, supported the growth of Micrococcus and prevented the growth of Staphylococcus. Its potential as a differential medium is considered worthy of clinical trial.

Journal: :Chemical communications 2014
Enrique E Maroto Marta Izquierdo Michihisa Murata Salvatore Filippone Koichi Komatsu Yasujiro Murata Nazario Martín

A complete stereocontrol of 1,3-dipolar cycloaddition of N-metalated azomethine ylides onto endohedral fullerene H2@C60 is reported for the first time. The stereodivergent synthesis of either the cis or the trans endohedral cycloadduct is achieved with excellent diastereo- and enantioselectivities.

Journal: :Journal of general microbiology 1973
D I Edwards M Dye H Carne

Three antimicrobial nitroimidazole drugs (metronidazole, dimetridazole, and tinidazole) inhibit a range of clostridia and the protozoan Trichomonas vaginalis ; they have an identical site and mode of action as specific electron acceptors from the pyruvate phosphoroclastic reaction. Analogues of the drugs are compared and the structural requirements for activity explained. The nitrofuran (nitrof...

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