BACKGROUND Hair dyes represent one of the most important causes of allergic contact dermatitis resulting from the use of cosmetic products. The principal causative chemistry is associated with oxidation products of p-phenylenediamine (PPD) and closely related substances. OBJECTIVES To examine whether prior application of the antioxidant vitamin C to the skin was able to reduce the cutaneous a...

Stevenson, Dobriner, and Rhoads (5) reported that p-dimethylaminoazobenzene when fed to rats is decomposed and metabolized to several simpler compounds. One of these split products, N,N-dimethylp-phenylenediamine, has been found by us ( i ) to be toxic to the glandular epithelium of the rat liver at concentrations of o.oooI M, while equivalent effects on the ductal epithelium were produced only...

Aromatic amines represent a category of classical environmental hazards which require biotransformation in order to exert their mutagenic and carcinogenic effects. The mutagenic activity of several aromatic amines was tested by means of the w/w+ somatic assay of Drosophila melanogaster employing a wild-type strain Leiden Standard (LS) and an insecticide-resistant stock Hikone-R (HK-R). Four mon...

The electron transport system of Acinetobacter sp. HO1-N was studied to determine the specific cytochromes and to measure changes in the composition of the respiratory system due to growth in various concentrations of oxygen or types of growth substrates. Spectrophotometric analysis revealed that the quantity and types of cytochromes changed in response to growth under various concentrations of...

The effects of cortisone treatment on oxygen consumption, oxidative phosphorylation, and fine structure of rat liver mitochondria have been studied. Male rats weighing 125 g were treated for 6 days with 5 mg of cortisone acetate or isotonic saline. On the 7th day, sections of liver were excised and processed for light and electron microscopy. Mitochondrial respiration and oxidative phosphorylat...

Aims of the STSM action: Molecularly imprinted polymers (MIPs) are stable, inexpensive and easy to produce. These advantages give MIP a great potential as a substitute for current bio-receptors like antibodies. But a lot of problem regarding to the application of MIP as recognition elements still need to be solved. The investigation of the MIP ability for bacterial detection potentially could b...

Aromatic amines belong to a group of compounds that exert their toxic effects usually after oxidative biotransformation, primarily in the liver. In addition, aromatic amines also undergo extrahepatic activation to yield free arylaminyl radicals. The reactive intermediates are potential promutagens and procarcinogens, and responsible for target tissue toxicity. Since thiols react with these inte...