نتایج جستجو برای: oxidative stress tissue damage
تعداد نتایج: 1507113 فیلتر نتایج به سال:
Acute pyelonephritis is a potentially life-threatening infection of the upper urinary tract. Inflammatory response and the accompanying oxidative stress can contribute to kidney tissue damage, resulting in infection-induced intoxication that can become fatal in the absence of antibiotic therapy. Here, we show that pyelonephritis was associated with oxidative stress and renal cell death. Oxidati...
Obesity-related glomerulopathy is an increasing cause of end-stage renal disease. Obesity has been considered a state of chronic low-grade systemic inflammation and chronic oxidative stress. Augmented inflammation in adipose and kidney tissues promotes the progression of kidney damage in obesity. Adipose tissue, which is accumulated in obesity, is a key endocrine organ that produces multiple bi...
Interest in the toxicological aspects of oxidative stress has grown in recent years, and research has become increasingly focused on the mechanistic aspects of oxidative damage and cellular responses in biological systems. Toxic consequences of oxidative stress at the subcellular level include lipid peroxidation and oxidative damage to DNA and proteins. These effects are often used as end point...
OBJECTIVES One cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. It has been shown that Chinese green tea (CGT) (Lung Chen Tea) has higher antioxidant property than black tea. In this paper, we will explore the preventive effect of CGT on cigarette smoke-indu...
Cities may expose wild animals to new types of selection pressures, potentially leading to differentiation among urban and rural populations. One cellular mechanism likely important in determining the viability of vertebrate populations is resistance to oxidative stress, as tissue degradation resulting from oxidative stress may decrease reproductive performance and survival. We hypothesized tha...
Mechanism of oxidative stress involved in the toxicity of ZnO nanoparticles against eukaryotic cells
ZnO NPs (zinc oxide nanoparticles) has generated significant scientific interest as a novel antibacterial and anticancer agent. Since oxidative stress is a critical determinant of ZnO NPs-induced damage, it is necessary to characterize their underlying mode of action. Different structural and physicochemical properties of ZnO NPs such as particle surface, size, shape, crystal structure, chemica...
Tissue damage caused by viral hepatitis is a major cause of morbidity and mortality worldwide. Using a mouse model of viral hepatitis, we identified virus-induced early transcriptional changes in the redox pathways in the liver, including downregulation of superoxide dismutase 1 (Sod1). Sod1(-/-) mice exhibited increased inflammation and aggravated liver damage upon viral infection, which was i...
BACKGROUND AND RATIONALE Portal hypertension (PHI) is a clinical syndrome characterized by increases of the blood flow and/or of the vascular resistance in the portal system. A direct consequence of PHI can appearance different lesions on the gastric mucosa and submucosa, cumulatively termed portal hypertensive gastropathy (PHG). AIMS To investigate the effects of glutamine on oxidative stres...
Background and purpose: Gestational diabetes is known as increasing blood glucose level for the first time during pregnancy. Mitochondrial damage and oxidative stress are the most important factors in the development of diabetic complications. Cerium nanoparticles have antioxidant properties. In this study we examined the protective effect of nanoceria in preventing mitochondrial damage induced...
Objective: Chronic stress plays an important role in the etiology of many inflammatory diseases. Reactive oxygen species (ROS), a source free radicals, act as signaling molecules progression stress-related Oxidative occurs result increase radicals tissues. The damage caused by oxidative can be reduced antioxidant replacement. In our study, effect fulvic acid, powerful antioxidant, on water avoi...
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