Several experimental and clinical studies have shown that oxidized low-density lipoprotein and oxidation-sensitive mechanisms are central in the pathogenesis of vascular dysfunction and atherogenesis. Here, we have used p66(Shc-/-) and WT mice to investigate the effects of high-fat diet on both systemic and tissue oxidative stress and the development of early vascular lesions. To date, the p66(...

The effects of SO2 and H2O on the low-temperature selective catalytic reduction (SCR) activity over MnOx/ZrO2/MWCNTs and MnOx/ZrO2/MWCNTs catalysts modified by Ce or Y was studied. MnCeZr and MnYZr catalysts reached nearly 100% and 93.9% NOx conversions at 200 ◦C and 240 ◦C, respectively. They displayed a better SO2 tolerance, and the effect of H2O was negligible. The structural properties of t...

BACKGROUND Patients with chronic pancreatitis (CP) are at high risk of antioxidant deficiencies. Furthermore, this disease can lead to diabetes mellitus (DM) that could exacerbate the severity of oxidative stress. Oxidative stress and the resulting LDL oxidation are a major cause of atherosclerosis. OBJECTIVE The objective of the study was to ascertain whether diabetes significantly modifies ...

Flavonoids are secondary plant metabolites; plants use them to attract pollinators and repel predators, to color flowers and fruits, and for other functions. Subclasses include isoflavones or phytoestrogens, catechins, anthocyanidins, and flavonols. Flavonoids contain benzene rings with multiple hydroxyl groups and they are therefore known as polyphenols. In 1936, Rusznyak and Szent-Gyorgyi (1)...

LDL resistance to oxidation is characterized by the lag time that precedes the rapid generation of conjugated dienes in copper-induced oxidation. Lag time (y) is described by the equation y = kx + a, where k is the efficacy constant of alpha-tocopherol (alpha-TOH), x the alpha-TOH content of LDL, and a the alpha-TOH-independent variable, all of which show considerable between-subject variabilit...

In vivo supplementation studies of the antioxidant alpha-tocopherol in human Type II diabetes have used surrogate, rather than direct, markers of oxidative damage/antioxidant protection and have used higher doses of alpha-tocopherol than used in coronary secondary prevention trials. We tested the hypothesis that oral alpha-tocopherol in a dosage regimen used in secondary prevention trials would...

Abstract Arsenic is a carcinogenic substance, with many cases of poisoning related to arsenic pollution in groundwater. In Taiwan groundwater caused the notorious Blackfoot disease. Methods for removal from water include precipitation, membrane processes, ion exchange, and adsorption, but these processing technologies suffer high investment costs complex operations. The traditional adsorption m...

a-Tocopherol is a classical lipophilic antioxidant well known as a scavenger of free radicals in a hydrophobic milieu. However, it can develop both antiand prooxidant activity in isolated low density lipoprotein (LDL). It is unknown how these activities are balanced in vivo in human plasma. We studied oxidation of plasma and LDL isolated from healthy donors or from a patient with familial isola...

background: a great deal of evidence has indicated that oxidatively modified ldl plays a critical role in the initiation and progression of atherosclerosis. antioxidants that can prevent ldl oxidation may act as antiatherogens. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper ions to ldl is usually thought to be a prerequisite for ldl oxidation by copper...

Background: A great deal of evidence has indicated that oxidatively modified LDL plays a critical role in the initiation and progression of atherosclerosis. Antioxidants that can prevent LDL oxidation may act as antiatherogens. Copper is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper ions to LDL is usually thought to be a prerequisite for LDL oxidation by copper...