نتایج جستجو برای: oxytocin
تعداد نتایج: 8587 فیلتر نتایج به سال:
BACKGROUND Oxytocin, a neurohypophyseal neuropeptide, is a potential mediator and regulator of drug addiction. However, the cellular mechanisms of oxytocin in drug seeking remain unknown. METHODS In the present study, we used a self-administration/reinstatement model to study the effects of oxytocin on cocaine seeking and its potential interaction with glutamate function at the receptor level...
We have previously shown that oxytocin receptors are present in the heart and that perfusion of isolated rat hearts with oxytocin results in decreased cardiac flow rate and bradycardia. The mechanisms involved in the negative inotropic and chronotropic effects of oxytocin were investigated in isolated dog right atria in the absence of central mechanisms. Perfusion of atria through the sinus nod...
BACKGROUND During pregnancy asthma may remain stable, improve or worsen. The factors underlying the deleterious effect of pregnancy on asthma remain unknown. Oxytocin is a neurohypophyseal protein that regulates a number of central and peripheral responses such as uterine contractions and milk ejection. Additional evidence suggests that oxytocin regulates inflammatory processes in other tissues...
The hypothalamic neuropeptide oxytocin attracts the attention of both the neuroscientific community and the general public, especially because of its prosocial effects. In the brain, this neuropeptide is synthesized in neurons exclusively located within the hypothalamic nuclei. Magnocellular neurons compose the larger population of oxytocinergic neurons, project to the posterior pituitary lobe ...
Background: Postpartum hemorrhage considered to be one of the most important cause of women mortality in developing countries. Usage of oxytocin is one of the outstanding success in medicine but it should not be taken for granted and should be used only if it is necessary and not as routine. Objective: To determine the amount of postpartum hemorrhage on the absence of IM injection of oxyt...
Background and purpose: Since bleeding due to the prolongation of the third stage of labor is one of the most common cause of mortality in the developing countries, we decided to conduct a comparative study on the effect of oxytocin and normal saline injected into umbilical vein on the shortening of the third stage of labor. Ïn referrees to Ïmam Khomeini delivery center of Sari in 1375. Ma...
Objectives: The aims of the present study were to compare the efficacy of oxytocin bolus alone, oxytocin bolus and infusion, carbetocin bolus alone, and carbetocin bolus followed by oxytocin infusion in reducing blood loss during and after cesarean section and reducing the needs for additional uterotonic agents. Methods: 200 women scheduled for elective CS under spinal anaesthesia were divided ...
Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which belongs to the G-protein-coupled receptor superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. Changes in receptor levels, receptor...
AIMS To study the effects of oxytocin on isolated rabbit distal colon and the regulation of ovarian steroids by its action. METHODS Muscle strips parallel to either the circular or the longitudinal fibres were excised and suspended in tissue chambers containing 5 mL Krebs solution (37 degrees C) and bubbled continuously with 95% O(2) and 5% CO(2). The effects of oxytocin on isometric spontane...
The transcriptional coactivator PGC-1α is a key regulator of cellular energy expenditure in peripheral tissues. Recent studies report that PGC-1α-null mice develop late-onset obesity and that the neuronal inactivation of PGC-1α causes increased food intake. However, the exact role of PGC-1α in the CNS remains unclear. Here we show that PGC-1α directly regulates the expression of the hypothalami...
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