نتایج جستجو برای: p53
تعداد نتایج: 42422 فیلتر نتایج به سال:
Protein-protein interactions (PPIs) intimately govern various biological processes and disease states therefore have been identified as attractive therapeutic targets for small-molecule drug discovery. However, the development of highly potent inhibitors PPIs has proven to be extremely challenging with limited clinical success stories. Herein, we report irreversible human double minute 2 (HDM2)...
background and aim: squamous cell carcinoma is the eighth common cancer and forms 94% of oral malignancies. nowadays, many molecular and genetic changes have been known to affect tumoral behavior which might be good for drug production and gene therapy. it has been known that mutated p53, overexpression of p63 as an oncogene and hpv infection are correlated with clinicopathological behavior of ...
conclusions despite the fact that abnormalities in p53 and p27kip1 may be involved in the development of oscc, their clinical significance in the studied population seems limited. further investigation on the combined p53/p27kip1 expression may be helpful in predicting the biologic behavior of this tumor. results p53 and p27kip1 expression were found in 28.57% (8 positive versus 20 negative) an...
Background: In prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. Stable p53 proteins in tumor cell nuclei have been associated with malignancy. A role of p53 is the regulation of drug transporters like ABCC1 (MRP1) by an effect on promoter region. Objectives: The objective of this study was to identify association...
<sec>P53 is well recognized to be a tumor suppressor protein. In response the external stress or environmental perturbation, p53 can promote transcription of various target genes downstream, thus regulating cell cycle, apoptosis, DNA repair, and angiogenesis. However, activation further activated by another protein, MDM2, which negatively regulates level inverse reduces p53. This phenomen...
سابقه و هدف: سرطان کولورکتال از سرطا ن های شایع جهانی می باشد . میزان شیوع سرطان کولورکتال بسته به ناحیه جغرافیایی متفاوت می باشد. در سرطان کولورکتال عوامل مختلفی از جمله رژیم غذایی، فاکتورهای محیطی و ژنتیکی نقش دارند . ژن P53 مهمترین ژن سرکو ب کننده تومور میباشد ، میزان جهش ژن P53 در سرطانهای کولورکتال در نواحی مختلف ، متفاوت گزارش شده است. هدف از این مطالعه تعیین جهش اکسون 6 ژن P53 در سرطان...
سابقه و هدف: سرطان کولورکتال یکی از مهمترین علل مرگ و میر و ناتوانی در جهان است. فقدان عملکرد پروتئین P53 و (P21(WAF1 یکی از مهمترین مکانیسم های تنظیمی دخیل در روند تشکیل سرطان کولورکتال و مؤثر در پیش آگهی و مقاومت درمانی می باشد. این مطالعه به منظور تعیین فراوانی بیان پروتئین P53 و P21 و ارتباط آن ها با شاخص های پاتولوژیک سرطان کولورکتال انجام شد. مواد و روشها: این مطالعه تحلیلی بر روی 70 نمون...
Background: Given the importance of differential diagnosis of different papillary urothelial cancers, expression, intensity and distribution of p53 were evaluated in different bladder cancers using immunohistochemistry. Materials and Methods: In a retrospective study, archived samples of patients with different papillary urothelial cancers in Shohaday-e-Khalij Fars Hospital were selected. The s...
human immunodeficiency virus (hiv) transactivator tat is a potent activator of both viral and cellu lar genes. tat has also been implicated in the development of aids-related malignancy. here, we show that tat physically and functionally is able to sequester the cell cycle check point protein p53. this sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin i...
background: in prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. stable p53 proteins in tumor cell nuclei have been associated with malignancy. a role of p53 is the regulation of drug transporters like abcc1 (mrp1) by an effect on promoter region.objectives: the objective of this study was to identify association ...
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