Background & Objective: Type1 diabetes is characterized by autoimmune destruction of pancreatic β cells, leading to reduced insulin secretion. Differentiation of mesenchymal stem cells (MSCs) into β-like cells offers new ways of diabetes treatment. MSCs can be insulated from the human umbilical cord tissue and differentiate into insulin-producing cells. Material & Methods: Human um...

Background: Data shows vanadium protects pancreatic beta cells (BC) from diabetic animals. Whether this effect is direct or through the relief of glucose toxicity is not clear. This study evaluated the potential effect of oral vanadyl sulfate (vanadium) on glycemic status and pancreatic BC of normal and diabetic rats. Methods: Rats were divided into five groups of normal and diabetic. Diabetes ...

Walnut is a medicinal plant that its different parts such as leaf, seed, root and green husk was shown to reduce blood glucose. In Iranian traditional medicine, septum of walnut shell (SWS) was recommended to reduce blood glucose. But this effect should be determined with scientific researches. Therefore, the aim of this study is to evaluate the effect of the aqueous extract of SWS on blood glu...

New biomarkers of pancreatic adenocarcinoma are needed to improve the early detection of this deadly disease. We performed surface enhanced laser desorption ionization (SELDI) mass spectrometry using ProteinChip technology (Ciphergen Biosystems, Fremont, CA) to screen for differentially expressed proteins in pancreatic juice. Pancreatic juice samples obtained from patients undergoing pancreatec...

Pancreatic pseudocysts arecomplications of acute and chronic pancreatitis. While most pancreatic are asymptomatic resolve spontaneously. Rarely, it could drain into the adjacent structure being a vessel, gastrointestinal structure, or open abdominal cavity. Rupture pseudocyst may lead to severe hemorrhage infection. However, few cases uncomplicated rupture were reported in literature. This case...

Endoscopic pancreatic stenting has been widely used in various pancreatic conditions. With the increasing use of pancreatic stents, many complications have been recognized. Especially, proximal stent migration presents a serious condition because of subsequent pancreatic duct obstruction, impaired drainage, ductal dilation, and pancreatic pain. Although endoscopic retrieval is the preferred tre...

abstract reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. it has been shown that progesterone and cilostazol possess antioxidant properties. the present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

Pancreatic heterotopia is a rare, unusual finding where pancreatic tissues are found out of the normal anatomical location. Various studies have documented an incidence 0.5 to 13% in autopsy. The reports on presence with estimated be around 0.2% all upper gastrointestinal surgeries. heterotopic pancreas occurs frequnetly stomach, duodenum and proximal jejunum. Remote cases Meckel's diverticulum...