T HE EXCITATORY FUNCTION of GABA has been reported to contribute to the pathogenesis of some neuropsychological disorders, for example autism and epilepsy. The switch in GABA function, from inhibitory to excitatory, has been attributed to the alteration of cation-chloride cotransporters involved in the regulation of intercellular chloride concentration, chloride-intruder NKCC1 and chlorideextru...

This study aimed to examine the convergent validity of the SSTICS. The association between the SSTICS and the five-factor model of the PANSS was also examined. One hundred and seventy-six schizophrenia-spectrum disorder patients were recruited. A correlation analysis was performed. The SSTICS score correlated with the score on the FPSES. The SSTICS score also correlated with the cognition facto...

In an open trial, drug-resistant schizophrenics were treated with clozapine for sixteen weeks. The patients were rated on BPRS, PANSS, Side effects scale and Global Impression Scale at weeks 0. 9 and 16. A battery of base-line investigations were done, and hemogram was repeated at weekly intervals. Of the total 29 patient included. 25 completed the trial. The patients showed significant improve...

BACKGROUND AND AIMS Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS 86 acutely psychotic patients treated with haloperidol were studied. RESULTS A PANSS reduction ≤16% at 1 week predicts non-response at 3 weeks of treatment (specificity 92%, sensitivity 82%). ...

After showing intermittent signs of psychosis for about 1 year, a 13-year-old boy was admitted to an inpatient psychiatric unit for increasingly bizarre behavior. The patient was experiencing typical symptoms of schizophrenia: paranoid delusions; hallucinations; fear and confusion; illogical thoughts; flat affect; and withdrawal from others. His Positive and Negative Syndrome Scale (PANSS) scor...

------------------------------------------------------ABSTRACT--------------------------------------------------With the advent of deinstitutionalization there is increasing interest in the quality of life of caregivers of patients of schizophrenia all over the world. Quality of life of 50 caregivers of schizophrenia patients were evaluated using Q-LES-Q-SF. Severity of Schizophrenia was evalua...