Novel synthetic mimics of antimicrobial peptides have been developed to exhibit structural properties and antimicrobial activity similar to those of natural antimicrobial peptides (AMPs) of the innate immune system. These molecules have a number of potential advantages over conventional antibiotics, including reduced bacterial resistance, cost-effective preparation, and customizable designs. In...

comNode classification within Membrane Residue Curves (M-RCMs) currently hinges on Lyapunov’s Theorem and therefore the computation of mathematically complex eigenvalues. This paper presents an alternative criterion for the classification of nodes within M-RCMs based on the total membrane flux at node compositions. This paper demonstrates that for a system exhibiting simple permeation behaviour...

in the present work, b-zsm-5 zeolite membranes were synthesized on porous tubular α-alumina supports by several subsequence in situ crystallization hydrothermal treatments. the tio2- bohmite and ɣ- alumina intermediate layers were applied to improve the lattice matching between zeolite layer and the support. the uniform membrane intermediate layers with low permeation resistance were prepared o...

this paper focuses on the effects of the addition of an ionic liquid, 1-allyl-3-butylimidazilium bis(trifluoromethane sulfonyl)imide ([abim]tfsi), which has a high affinity for benzene, into the poly(vinyl chloride) (pvc) membrane on the pervaporation characteristics of the removal of benzene from aqueous solutions of dilute benzene. when aqueous solutions of 100～500 ppm benzene were permeated ...

In the present work, B-ZSM-5 zeolite membranes were synthesized on porous tubular α-alumina supports by several subsequence in situ crystallization hydrothermal treatments. The TiO2- Bohmite and ɣ- alumina intermediate layers were applied to improve the lattice matching between zeolite layer and the support. The uniform membrane intermediate layers with low permeation resistance were...

Voltage-gated calcium (Ca(V)) channels deliver Ca(2+) to trigger cellular functions ranging from cardiac muscle contraction to neurotransmitter release. The mechanism by which these channels select for Ca(2+) over other cations is thought to involve multiple Ca(2+)-binding sites within the pore. Although the Ca(2+) affinity and cation preference of these sites have been extensively investigated...

Crystal structures of several bacterial Na(v) channels have been recently published and molecular dynamics simulations of ion permeation through these channels are consistent with many electrophysiological properties of eukaryotic channels. Bacterial Na(v) channels have been characterized as functionally asymmetric, and the mechanism of this asymmetry has not been clearly understood. To address...

Determination of a high-resolution 3D structure of voltage-gated sodium channel Na(V)Ab opens the way to elucidating the mechanism of ion conductance and selectivity. To examine permeation of Na(+) through the selectivity filter of the channel, we performed large-scale molecular dynamics simulations of Na(V)Ab in an explicit, hydrated lipid bilayer at 0 mV in 150 mM NaCl, for a total simulation...