نتایج جستجو برای: permeation mechanism

تعداد نتایج: 573606  

Journal: :iranian journal of pharmaceutical research 0
jun shi 1- school of pharmacy, east china university of science and technology, shanghai 200237, pr china. 2- department of chemistry, tsinghua university, beijing 100084, pr china. wen-juan cong engineering research center of modern preparation technology of tcm (ministry of education), shanghai university of traditional chinese medicine, shanghai 201203, pr china. yi-ming wang department of chemistry, tsinghua university, beijing 100084, pr china. qing-fei liu school of medicine, tsinghua university, beijing 100084, pr china. guo-an luo 1- school of pharmacy, east china university of science and technology, shanghai 200237, pr china. 2- department of chemistry, tsinghua university, beijing 100084, pr china.

the aim of the present study was to investigate the influence and the mechanisms of cineoleand terpineol on the in-vitro transdermal delivery of huperzine a from microemulsions, andtheir potential synergistic effect on the permeation enhancement. the transdermal deliveryof huperzine a from microemulsions with different concentrations of cineole and terpineolthrough the rat abdominal skin was de...

2015
Dan D. Koo

Although permeation of hydrocarbons such as Benzene, Toluene, Ethybenzene, and Xylene (BTEX) through polyethylene (PE) pipe in potable water applications is rarely occurred. It is important to understand permeation mechanism and characterize the potential health risk. The most common potential hydrocarbon substances are originated from gasoline leaks. Previous research has shown that pipe mater...

Journal: :International Journal of Pharmaceutics: X 2019

In recent years, plasma treatments have given good results since they offer high technological efficiency with low waste generation. One of the most important characteristics of plasma methods is their action only on a thin surface layer, whereas the bulk of sample remains unchanged and the modified material keeps its chemical and mechanical properties. In this research, polyurethane membrane s...

Journal: :iranian journal of basic medical sciences 0
elham khodaverdi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran pharmaceutical research center, avicenna institute, mashhad university of medical sciences, mashhad, iran omid rajabi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran pharmaceutical research center, avicenna institute, mashhad university of medical sciences, mashhad, iran farshad farhadi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran afshin jalali department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) physiological changes in the body may be utilized as potential triggers for controlled drug delivery. based on these mechanisms, stimulus-responsive drug delivery has been developed. materials and methods in this study, a kind of poly (n-isopropylacrylamide-acrylamide) membrane was prepared by radical copolymerization. changes in swelling ratios and diameters of the membrane were i...

2016
Patricia M. G. E. Brown Mark R. P. Aurousseau Maria Musgaard Philip C. Biggin Derek Bowie

KEY POINTS Kainate receptor heteromerization and auxiliary subunits, Neto1 and Neto2, attenuate polyamine ion-channel block by facilitating blocker permeation. Relief of polyamine block in GluK2/GluK5 heteromers results from a key proline residue that produces architectural changes in the channel pore α-helical region. Auxiliary subunits exert an additive effect to heteromerization, and thus re...

2009
Ilja V. Khavrutskii Alemayehu A. Gorfe Benzhuo Lu J. Andrew McCammon

Understanding the mechanism of ion permeation across lipid bilayers is key to controlling osmotic pressure and developing new ways of delivering charged, drug-like molecules inside cells. Recent reports suggest ion-pairing as the mechanism to lower the free energy barrier for the ion permeation in disagreement with predictions from the simple electrostatic models. In this paper we quantify the ...

2013
Morten Ø. Jensen Vishwanath Jogini Michael P. Eastwood David E. Shaw

The difficulty in characterizing ion conduction through membrane channels at the level of individual permeation events has made it challenging to elucidate the mechanistic principles underpinning this fundamental physiological process. Using long, all-atom simulations enabled by special-purpose hardware, we studied K(+) permeation across the KV1.2/2.1 voltage-gated potassium channel. At experim...

Journal: :Journal of Nanobiotechnology 2008
Faiyaz Shakeel Sanjula Baboota Alka Ahuja Javed Ali Sheikh Shafiq

BACKGROUND Celecoxib, a selective cyclo-oxygenase-2 inhibitor has been recommended orally for the treatment of arthritis and osteoarthritis. Long term oral administration of celecoxib produces serious gastrointestinal side effects. It is a highly lipophilic, poorly soluble drug with oral bioavailability of around 40% (Capsule). Therefore the aim of the present investigation was to assess the sk...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه گیلان - دانشکده فنی 1393

asymmetric membranes are widely used in many industrial membrane separation processes. the major advantage of membrane filtration over the conventional process is its ability to remove a wider spectrum of particles without using any chemicals. hollow fiber configuration offer many advantages over flat-sheet or tubular membranes. the spinning process of hollow fiber may look simple, yet it is te...

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