This article discusses the relative contraindications to the use of vasoconstrictor in patients currently medicated with tricyciic antidepressants, monoamine oxidase inhibitors, phenothiazines and P-blockers. It reviews drug interactions and emphasizes potential detrimental systemic effects that epinephrine contained in !ocal anesthetics can have when administered concomitantly with these drugs...

T. cruzi enzimes such as trypanothione reductase, represent potential drugs targets because they play an essential role in the life of this organism. This enzyme has been isolated, purified and studied by X ray cristalography. Phenothiazines and related compounds inhibit trypanothione reductase and a specially favoured fit is a small 2 -substitued 2-chloro and 2-trifluoromethyl with a remote hy...

The first antipsychotic, chlorpromazine, was used for the treatment of psychosis in France in 1951 and in the United States in 1954. Antipsychotic use has expanded significantly since then. The historic term neuroleptic, used with antipsychotic medication, is no longer appropriate because newer agents cause less sedation. The term antipsychotic is now preferred. In 2009, U.S. poison control cen...

Chlorpromazine and thioridazine are phenothiazines employed in the treatment of psychosis. These agents inhibited the respiration of clinical isolates of Mycobacterium tuberculosis resistant to streptomycin, rifampin, isoniazid, ethambutol and/or pyrazinamid, all first line drugs. Since any adverse reaction to thioridazine is generally less severe than to chlorpromazine, the possibility is attr...

The effect of phenothiazines (trifluoperazine and chlorpromazine) on cholesteryl ester metabolism has been investigated in J 774 mouse monocyte-macrophages. The incorporation of oleic acid into cholesteryl ester and the activity of acylcoenzyme A: cholesterol-O-acyltransferase were strongly decreased in cells pretreated for 24 h with trifluoperazine or chlorpromazine. Furthermore, trifluoperazi...

Lymphoma is one of the most common malignant tumors in canine. Protein phosphatase 2A (PP2A), a well-conserved serine/threonine phosphatase, plays a critical role as a tumor suppressor. Perphenazine (PPZ) is one of the phenothiazines and widely used as an antipsychotic drug. Recently, it is reported that PPZ directly binds with scaffolding subunit of PP2A complex and exerts anti-tumor effects o...