10H-phenothiazines are prepared by Smiles rearrangement. These prepared phenothiazines are used as base to prepare ribofuranosides by treatment with β-Dribofuranosyl-1-acetate-2,3,5-tribenzoate. 10H-Phenothiazines on refluxing with hydrogen peroxide in glacial acetic acid gave 10H-phenothiazine-5,5-dioxides. Their antioxidant and antimicrobial activity have been carried out. The structure of th...

The gram-negative soil bacillus Burkholderia pseudomallei is the causative agent of melioidosis, a severe and potentially fatal septicemic disease that is endemic to Southeast Asia and northern Australia. Its intrinsic resistance to many antibiotics is attributed mainly to the presence of several drug efflux pumps, and therefore, inhibitors of such pumps are expected to restore the activities o...

Rising cases of antibiotic-resistant bacteria is a public health concern. Many approved antibiotics target penicillin-binding proteins example peptidoglycan transpeptidase (PTPase). Due to wide pharmacological activity of phenothiazines, new styryl, aryl, alkynyl, and thiophenyl benzo[a]phenothiazines were synthesized and their inhibitory potency against PTPasein silico and Gram-po...

OBJECTIVE AND BACKGROUND Ranges of agents are used in the emergency departments to treat migraine headache. Some experts suggest that phenothiazines are among the most effective; clinical trials have been small with varied results. We performed a systematic review and meta-analysis to determine the relative effectiveness of phenothiazines compared with placebo and other active agents for the tr...

2,10-Disubstituted phenothiazines are the best drugs in psychiatry. Several methods for their analysis have been reported in the literature. The official methods are based on non-aqueous titration or spectrophotometry. Various oxidizing agents have been used for the spectrophotometric determination of 2,10-disubstituted phenothiazines, e.g. Ce(SO4)2, NH4VO3, K2S208, KIO4, KIO3, KBrO3, FeCl3, Na...

Preassociation of the substrate close to photoredox catalyst increases its efficiency, shown using pillarene-bound phenothiazines in reduction alkyl bromides.

Phenothiazines are known to be among the compounds that reverse or modulate the multidrug resistance (MDR) of cancer cells. There is much evidence that the interactions of these reversal agents with the lipid phase of the plasma membrane are involved in the mechanism of MDR reversal. In this study, two parameters of a set of commercial phenothiazines were estimated: the phosphatidylocholine ves...