Objective: This work aimed of to review the implications anti-TNF-α therapy in COVID-19 patients associated with genetic polymorphism (TNF-α polymorphisms region-308) this pertinent cytokine Methodology: Electronic searches were carried out on PUBMED Central, BVS/BIREME, Web Science and The Cochrane Library aid key-words. Results: Twenty-six articles collected. Anti-TNF-α was interpreted evalua...

Estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. Estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. Estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. Estrogen receptors are found in many tissues that participate in the pathogenesis of ty...

Background: Many studies have reported the association of estrogen receptor α gene (ESRα) ESRα PvuII T>C, XbaI A>G and BtgI G>A polymorphisms with Knee osteoarthritis (KOA) risk, but the results remained controversial. In order to drive a more precise estimation, the present systematic review and meta-analysis was performed to investigate the association between ESRα polymorphisms and KOA susce...

Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. We aimed to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. PubMed, Web of Science, Google Scholar, an...

Background: One of the limitations in the treatment of common diseases such as cancer chemotherapy is development of multidrug re‌sistance (MDR). Polymorphisms could alter the expression level of MDR1 gene, which plays an important role in MDR. In this research, the frequency of C3435T, C1236T, and G2677T/A polymorphisms of MDR1 gene was investigated in a large group of population from Hamadan ...

Objective(s): Asthma results from the interaction between genetic and environmental factors. ADAM33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. Materials and Methods: This is a case-control study, where four SNPs S1 (rs3918396), T1 (rs2280091), T2 (rs2280090), V4 (rs2787094) of ADAM33 gene have been assessed in patients with allergic asthma and normal con...

Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously a...