Objective(s): The aim of the present study was to assess the effects of vitamin C (Vit C) on hemolytic anemia induced by phenylhydrazine (PHZ). Materials and Methods: Twenty-four healthy male mice were divided into four groups, randomly: Control group (0.1 ml/day, normal slaine, IP), PHZ group that received only PHZ 8 mg/100 g/48 hr, IP, PHZ+Vit C group that received PHZ 8 mg/100 g/48 hr, IP an...

Busulfan is an alkylating agent affects ovarian follicles growth by oxidative stress induction. Satureja khuzestanica has antioxidant effects. The aim of this study was to examine whether S. khuzestanica essential oil (SKEO) exhibits protective effects on busulfan-induced ovarian failure. Eighty-four adult female mice were divided into six groups including dimethyl sulfoxide (...

Electrical storm after Left Ventricular Assist Device (LVAD) is a recognized complication. The risk factors associated with electrical storm, impact on survival less studied. aim of this study to the incidence, LVAD implantation and in patients undergoing LVAD. We performed retrospective cohort all who underwent from January 1, 2001, December 31, 2020, at Mayo Clinic (Rochester, Phoenix, Jackso...

OBJECTIVES We sought to determine whether direct stenting might prevent the adverse events associated with stent implantation during primary angioplasty and to compare it with conventional stent implantation in patients with acute myocardial infarction (AMI). BACKGROUND No trial has demonstrated that stents favorably influence mortality rate. Recent studies have even suggested a negative impact...

Mouse models are commonly used for studying hepatocellular carcinoma (HCC) biology and exploring new therapeutic interventions. Currently three main modalities of HCC mouse models have been extensively employed in pre-clinical studies including chemically induced, transgenic and transplantation models. Among them, transplantation models are preferred for evaluating in vivo drug efficacy in pre-...

Serotonin is reported to be present in early embryos of many species and plays an important role in early patterning. Since it is a fluorophore, it can be directly visualized using fluorescence microscopy. Here, we use three-photon microscopy to image serotonin in live pre-implantation mouse embryos. We find that it is present as puncta averaging 1.3 square microns and in concentrations as high...

Metastatic pancreatic adenocarcinoma (mPDAC) has a poor prognosis with 5-year survival rate of 3%. In non-metastatic, unresectable locally advanced cancer (LAPC) patients, endoscopic-ultrasound (EUS)-guided intra-tumoral phosphorus-32 ( 32 P)-microparticles implantation resulted in local disease control [LDCR] (defined as Stable Disease [SD] or better) at 16 weeks (3 months post-implantation) 9...