Gene targeting in human somatic cells is of importance because it can be used to either delineate the loss-of-function phenotype of a gene or correct a mutated gene back to wild-type. Both of these outcomes require a form of DNA double-strand break (DSB) repair known as homologous recombination (HR). The mechanism of HR leading to gene targeting, however, is not well understood in human cells. ...

This report reevaluates PROGRESA’s targeting methods since the program began adding beneficiary households through a process called “densification.” The authors first evaluate PROGRESA’s accuracy in targeting both at the community and household levels. Second, they evaluate the targeting in terms of its impact on poverty alleviation relative to other feasible methods assuming the same total bud...

Kalcic, Margaret McCahon. Ph.D., Purdue University, December 2013. Adaptive Targeting: Engaging Farmers to Assess Perceptions and Improve Watershed Modeling, Optimization, and Adoption of Agricultural Conservation Practices. Major Professors: Jane Frankenberger and Indrajeet Chaubey. Targeting agricultural conservation practices to farmland that has the greatest impact on surface water quality ...

This paper presents a new non parametric atlas registration framework, derived from the optical flow model and the active contour theory, applied to automatic subthalamic nucleus (STN) targeting in deep brain stimulation (DBS) surgery. In a previous work, we demonstrated that the STN position can be predicted based on the position of surrounding visible structures, namely the lateral and third ...

Angiogenesis is a critical process in numerous diseases, and intervention in neovascularization has therapeutic value in several disease settings, including ocular diseases, arthritis, and in tumor progression and metastatic spread. Various vascular targeting agents have been developed, including those that inhibit growth factor receptor tyrosine kinases, blocking antibodies that interfere with...