this paper is devoted to the study of determining optimal process mean in system production with the two markets for the sale of goods. in this paper, we developed an absorbing markov chain model in production systems where all items are inspected %100 for conformance with their specification limits. when the value of the quality characteristic of an item falls below a lower limit, the item is ...

Customers and consumers are the necessities for the survival of industries and organizations. Trying to improve the process in order to increase consumer satisfaction is the most important aim. The survival of an organization depends on its ability to continue the activities in compliance with the demands of customers to meet their legitimate needs. An organization is successful when it exactly...

the present study , was an attempt to develop galactosylated albumin nanoparticles of simvastatin for treatment of hypercholesterolemia. by developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. the advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to t...

Process adjustment, also known as process targeting, is one of the classical problems in the field of quality control and production economics. In the process adjustment problem, it is assumed that process parameters are variables and the aim is to determine these parameters such that certain economic criteria are optimally satisfied. The aim of this paper is to determine the optimal process ad...

multifunctional nanomaterials showed graet advantages in drug delivery. folic acid (fa) binding protein, a glycosyl phosphatidyl inositol anchored cell surface receptor for folate, is overexpressed in several human tumors, whereas it is highly restricted in normal tissues. therefore, in this study, fa, polyethylene glycol (peg), and fe3o4 nanoparticles multifunctionalized short multiwall carbon...

Argonaute proteins play a central role in mediating post-transcriptional gene regulation by microRNAs (miRNAs). Argonautes use the nucleotide sequences in miRNAs as guides for identifying target messenger RNAs for repression. Here, we used single-molecule FRET to directly visualize how human Argonaute-2 (Ago2) searches for and identifies target sites in RNAs complementary to its miRNA guide. Ou...

Constrained target clustering (CTC) is proposed to support the targeting decision-making in the network centric warfare environment. When area targets are detected by sensors, it is required to decide the points at which a missile or bomb is aimed to achieve operational goals. CTC can determine the optimal numbers and positions of aiming points by transforming the targeting problem into cluster...