CONTEXT Papillary thyroid carcinoma (PTC) in patients exposed to environmental radioiodine after the Chernobyl accident is thought to have a relatively aggressive clinical course. Long-term results of treatment are not well known, especially in comparison with sporadic PTC. OBJECTIVE The determination of risk factors for PTC recurrence in a controlled for baseline factors group of patients wi...

Accumulating evidence has suggested that microRNAs (miRNAs) are involved in multiple processes in cancer development and progression by negatively regulating gene expression at posttranscriptional level. Recent studies have shown that miR-23a functions as an oncogene in many types cancer, but its role in papillary thyroid carcinoma (PTC) remains poorly understood. The aim of this study is to in...

The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. To further investigate this hypothesis, we submitted Ptc(+/-) heterozygous mutant mice and their wild-type l...

Aberrant messenger RNAs containing a premature termination codon (PTC) are eliminated by the nonsense-mediated mRNA decay (NMD) pathway. Here, we show that a crucial NMD factor, up frameshift 1 protein (Upf1), is required for rapid proteasome-mediated degradation of an aberrant protein (PTC product) derived from a PTC-containing mRNA. Western blot and pulse-chase analyses revealed that Upf1 sti...

Parathyroid carcinoma (PTC) is an infrequent pathology, responsible for 0.5-5% of primary hyperparathyroidism’s [1,2]. Despite the high frequency of secondary hyperparathyroidism in chronic kidney disease (CKD) patients, PTC is extremely rare, with less than 30 cases reported in the literature [3-5]. The diagnosis of PTC is difficult. Usually presents symptoms and signs of Hypercalcemia: fatigu...

This paper introduces a lab project developed for the Summer Teachers’ Workshop in Genomics at Amherst College, and is easily tailored to the weekly format of undergraduate laboratory courses in genetics, genomics, molecular biology, or evolution. The project examines single nucleotide polymorphisms associated with human taste sensitivity to the bitter compound phenylthiocarbamide (PTC). Human ...

BACKGROUND To investigate the clinicopathological features of recurrent papillary thyroid carcinoma (PTC). METHODS A retrospective analysis on clinical and pathological data of 34 patients with recurrent PTC was carried out. A total of 281 patients with non-recurrent PTC during the same time period were chosen as the control group. RESULTS Patients were divided into three groups according t...

PURPOSE Despite recent studies showing that vascular endothelial growth factor C (VEGF-C) mRNA is up-regulated in papillary thyroid carcinoma (PTC), the role of VEGF-C in lymph node metastasis is still unclear. The aim of this study is to investigate the expression pattern of VEGF-C immunoreactive protein in PTC and its relationship with cervical lymph node metastasis. EXPERIMENTAL DESIGN Tis...

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Elucidating the molecular network that is altered in PTC may lead to the identification of the critical insight into the pathogenesis of PTC. Thus far, little is known regarding the global metabolomic alterations of PTC. Gas chromatography coupled with mass spectrometry-based metabolomics was used to analyze metabolomi...

Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo comple...