The comparative analysis of the expression reactive oxygen species-generating NADPH oxidase NOX4 from TCGA data shows that transcript is upregulated in papillary thyroid carcinomas (PTC)-BRAFV600E tumors compared to PTC-BRAFwt tumors. However, a at protein level malignant and non-malignant missing. We explored by immunohistochemistry staining (28 classical forms PTC (C-PTC), 17 follicular varia...

objective: pseudotumor cerbri (ptc) is a clinical syndrome characterized by increased intra-cranial pressure (icp) without any evidence of a mass lesion or any obstructive process. the incidence is 0.9-2 per 100.000 people. it is more frequent in adults in the 20-30 years age group, especially obese women, and less common in pediatric age groups; 11-16 years old children may however suffer from...

the coexistence of medullary thyroid carcinoma (mtc), papillary thyroid carcinoma (ptc) and parathyroid adenoma is an uncommon clinical entity. here, we report a case of mtc, ptc, and parathyroid adenoma diagnosed incidentally on a routine physical examination of the neck for the work-up of diabetes. the patient had neither symptoms of hypercalcemia nor those related to mtc and ptc.

PURPOSE Papillary thyroid carcinoma (PTC), the most common thyroid malignancy, usually possesses BRAF mutation or rearranged in translation (RET)/PTC rearrangements. PTC usually possesses BRAF mutation or RET/PTC rearrangements. The mutation status of patients with recurrent PTC has never been characterized in a large population. EXPERIMENTAL DESIGN Mutation status was determined in a cohort ...

The nematode Caenorhabditis elegans has retained a rudimentary Hedgehog (Hh) signalling pathway; Hh and Smoothened (Smo) homologs are absent, but two highly related Patched gene homologs, ptc-1 and ptc-3, and 24 ptc-related (ptr) genes are present. We previously showed that ptc-1 is essential for germ line cytokinesis. Here, we report that ptc-3 is also an essential gene; the absence of ptc-3 r...