The mol-ecule of the title compound, C(8)H(3)Cl(2)FN(2), is essentially planar, with a maximum deviation of 0.018 (2) Å. In the crystal, π-π stacking is observed between parallel quinazoline moieties of adjacent mol-ecules, the centroid-centroid distance being 3.8476 (14) Å.

In the title compound, C(22)H(27)ClN(6)O(2) (2+)·2ClO(4) (-), the mol-ecule adopts an E conformation about the C=N double bond. The quinazoline ring is approximately planar, with an r.m.s. deviation of 0.0432 Å, and forms a dihedral angle of 5.77 (4)° with the chloro-phenyl ring. The crystal packing features N-H⋯O hydrogen bonds.

Copper(II) acetate/acetic acid/O2 and potassium iodide/tert-butylhydroperoxide systems are shown to affect the selective oxidation of ring-fused aminals to dihydroquinazolines and quinazolinones, respectively. These methods enable the facile preparation of a number of quinazoline alkaloid natural products and their analogues.

A series of chiral 6-membered ring N-heterocyclic carbene (NHC) precursors based on 3,4-dihydro-quinazoline were synthesized with overall yields of 54-62%. NHCs generated from these precursors show excellent asymmetric catalytic properties for borylation of α,β-unsaturated esters with enantioselectivity of up to 93% with a catalyst content of only 1 mol%.

We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2-halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.

A method for the Pd-catalyzed N-arylation of both aryl and alkyl amidines with a wide range of aryl bromides, chlorides, and triflates is described. The reactions proceed in short reaction times and with excellent selectivity for monoarylation. A one-pot synthesis of quinazoline derivatives, via addition of an aldehyde to the crude reaction mixture following Pd-catalyzed N-arylation, is also de...

In the title compound, C(11)H(9)N(3)O, the quinazoline unit is almost planar, with a mean deviation of 0.006 (1) Å from the least-squares plane defined by the ten constituent atoms. In the crystal, mol-ecules are linked by weak C-H⋯N hydrogen bonds.

The novel quinazoline metabolite serantrypinone (1) has been isolated from an isolate of the microfungus Penicillium thymicola together with daldinin D (2), a new peracetylated spiro azaphilone derivative. The structures of 1 and 2 were elucidated by analysis of spectroscopic data, including 2D NMR, and comparison with literature data.

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 3 INVESTIGATING THE FLUOROQUINOLONE-TOPOISOMERASE INTERACTION BY USE OF NOVEL FLUOROQUINOLONE AND QUINAZOLINE ANALOGS by Kevin Randall Marks A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy ...