نتایج جستجو برای: quinazoline

تعداد نتایج: 941  

2014
Mohammed B. Alshammari Keith Smith Amany S. Hegazy Benson M. Kariuki Gamal A. El-Hiti

In the title compound, C15H12N2S, the methylthioquinazoline group is planar with the methyl C displaced by only 0.116 (3) Å from the plane of the quinazoline moiety. The dihedral angle between the phenyl ring and the quinazoline ring system is 13.95 (5)°. In the crystal, each molecule is linked by π-π stacking between to two adjacent inversion-related molecules. On one side, the inverted quinaz...

Journal: :Chemical communications 2014
Smita Nahar Debojit Bose Sumit Kumar Panja Satyen Saha Souvik Maiti

Three quinazoline based small molecules showed global upregulation of miRNA expression with a selective enrichment of tumor suppressor miRNAs. The target genes of the upregulated miRNAs were predicted to be enriched for apoptotic pathways. Apoptotic induction following treatment with quinazoline compounds was confirmed by in cellulo studies. Thus, these small molecules having the core structura...

Journal: :Cell chemical biology 2017
Mei Zeng Jia Lu Lianbo Li Frederic Feru Chunshan Quan Thomas W Gero Scott B Ficarro Yuan Xiong Chiara Ambrogio Raymond M Paranal Marco Catalano Jay Shao Kwok-Kin Wong Jarrod A Marto Eric S Fischer Pasi A Jänne David A Scott Kenneth D Westover Nathanael S Gray

Targeted covalent small molecules have shown promise for cancers driven by KRAS G12C. Allosteric compounds that access an inducible pocket formed by movement of a dynamic structural element in KRAS, switch II, have been reported, but these compounds require further optimization to enable their advancement into clinical development. We demonstrate that covalent quinazoline-based switch II pocket...

Journal: :Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2005
Renáta Ovádeková Sona Jantová Marica Theiszová Ján Labuda

Quinazolines - 1,3-benzodiazines are biological active compounds, which are used in the phamaceutical industry, in agriculture and in the medicine. As documented in the literature, many derivatives demonstrated anticancer activity and they act as multitarget agents. 3-(5-Nitro-2-thienyl)-9-chloro-5-morpholin-4-yl[1,2,4]triazolo[4,3-c] quinazoline (NTCHMTQ) - a new synthetically prepared quinazo...

Journal: :Acta crystallographica. Section C, Crystal structure communications 2005
Jaime Portilla Jairo Quiroga Justo Cobo Manuel Nogueras John N Low Christopher Glidewell

Molecules of 5-methyl-2-phenyl-6,7-dihydrobenzo[h]pyrazolo[1,5-a]quinazoline, C21H17N3, (I), are linked into chains by a combination of a C-H...pi(arene) hydrogen bond and a pi-pi stacking interaction; in the closely related 5-methyl-2-(4-methylphenyl)-6,7-dihydrobenzo[h]pyrazolo[1,5-a]quinazoline, C22H19N3, (II), there are no hydrogen bonds and the molecules are linked into centrosymmetric dim...

Journal: :iranian journal of basic medical sciences 0
zeng li department of pharmacy, anhui medical university, hefei 230032, china bin wang department of pharmacy, xiangnan university, chenzhou 423000, china liang tang department of chirurgery, first affiliated hospital of anhui medical university, hefei 230032, china shuangsheng chen department of pharmacy, anhui medical university, hefei 230032, china department of chirurgery, first affiliated hospital of anhui medical university, hefei 230032, china jun li department of pharmacy, anhui medical university, hefei 230032, china

objective(s): we previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. in this study, we investigated the mechanism underlying the anti-angiogenic activity of the quinazoline derivative compound 11d. materials and methods: we examined the effects of quinazoline derivative 11d on vascular endothelial growth factor receptor-2 (vegfr2) activation via vegf...

Journal: :Biological research 2008
Gloria D Galarce Rocío E Foncea Ana M Edwards Hernán Pessoa-Mahana Carlos D Pessoa-Mahana Roberto A Ebensperger

This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-alpha secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo[1,2-c]quinazoline, coded as...

2013
Haider Behbehani Hamada Mohamed Ibrahim

BACKGROUND There are only limited publications devoted to the synthesis of especially thiazolo[3,2-a]quinazoline which involved reaction of 2-mercaptopropargyl quinazolin-4-one with various aryl iodides catalyzed by Pd-Cu or by condensation of 2-mercapto-4-oxoquinazoline with chloroacetic acid, inspite of this procedure was also reported in the literature to afford the thiazolo [2,3-b] quinazol...

Journal: :Molecules 2014
Abdelaaziz Ouahrouch Moha Taourirte Joachim W Engels Soumaya Benjelloun Hassan B Lazrek

In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O-benzoylribose or activated alkylating agents under microwave conditions. None of the compounds selected showed significant anti-HCV activity in vitro.

2015
Sukriti Srivastava Sujiti Srivastava

Abstract: The aim of this review is to provide an overview of diverse pharmacological activities of quinazoline moiety. Quinazoline are well known and important nitrogen containing heterocyclic compound made chemical formula C8H6N2 and various methods have been worked out for their synthesis. Quinazoline has become a popular topic up of two fused six-membered simple aromatic rings, a benzene ri...

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