The emergence of chloroquine resistance, and a world-wide scarcity of quinine, have resulted in a search for newer antimalarial drugs directed against falciparum malaria. Allopurinol causes virtually complete inhibition of purine biosynthesis of malaria parasites, which may prove lethal to the parasites. This study was designed to examine if allopurinol is additive to quinine in the treatment o...

This paper presents the IMine index, a general and compact structure which provides tight integration of item set extraction in a relational DBMS. Since no constraint is enforced during the index creation phase, IMine provides a complete representation of the original database. To reduce the I/O cost, data accessed together during the same extraction phase are clustered on the same disk block. ...

Large amounts (>100 mol equivalents) of water are required to effect by hydrolysis the partial disassembly of the rings from the dumbbell components of two dynamic [2]rotaxanes. The two dynamic [2]rotaxanes are comprised of [24]crown-8 rings-each of which incorporate two imine bonds-encircling a dumbbell component composed of a dibenzylammonium ion in which each of the two benzyl substituents c...

CKX (cytokinin dehydrogenase) is a flavoprotein that cleaves cytokinins to adenine and the corresponding side-chain aldehyde using a quinone-type electron acceptor. In the present study, reactions of maize (Zea mays) CKX with five different substrates (N6-isopentenyladenine, trans-zeatin, kinetin, p-topolin and N-methyl-isopentenyladenine) were studied. By using stopped-flow analysis of the red...

Ab initio and DFT calculations reveal that both imidoyl and thioyl radicals add to the nitrogen end of methanimine through simultaneous SOMO-π*(imine), SOMO-π(imine), SOMO-LP(N) and π*(radical)-LP(N) interactions between the radical and the imine. At the CCSD(T)/cc-pVDZ//BHandHLYP/cc-pVTZ level of theory, barriers of 13.8 and 26.1 kJ mol(-1) are calculated for the attack of the methylimidoyl ra...

PURPOSE Leg cramps are common in patients with heart failure. Quinine is frequently prescribed in low doses to these patients, but safety of this practice is unknown. We studied the outcomes associated with use of quinine in a nationwide cohort of patients with heart failure. METHODS Through individual-level-linkage of Danish national registries, we identified patients discharged from first-t...

was a clear association with malaria, and that all these four cases responded well to treatment with quinine, whereas the other two patients were discharged with evidence of permanently damaged kidneys. Another report of his observations was published in 1942. His main evidence of the malarial origin of the subacute glomerular nephrosis which he described is the response to quinine, and thus he...

Sir,?Owing to the shortage of quinine by-hydrochloride may we draw attention to the following method of using quinine sulphate for intramuscular injections which we have found to be successful in malaria ? About 6,000 injections have been given in the past 12 months without any abscess formation and the therapeutic results have been as satisfactory as quinine bi-liydrochloride. Even infants, a ...

2. In all cases the results indicate that the total alkaloids have an effect similar to, or even better than, that of quinine. 3. Industrial and laboratory preparations are of equal value. 4. The total alkaloids from which the quinine has beenextractedhave apoortherapeutic effect, andthe difference between these and the results with the total alkaloids may be due to the synergistic action of sm...

The relationship between specific gustatory nerve activity and central patterns of taste-evoked neuronal activation is poorly understood. To address this issue within the first central synaptic relay in the gustatory system, we examined the distribution of neurons in the nucleus of the solitary tract (NST) activated by the intraoral infusion of quinine using Fos immunohistochemistry in rats wit...