نتایج جستجو برای: quinine imine

تعداد نتایج: 5773  

2017
Chun-Zhi Ai Yong Liu Wei Li De-Meng Chen Xin-Xing Zhu Ya-Wei Yan Du-Chu Chen Yi-Zhou Jiang

EGFR inhibitors, even with therapeutics superiorities in anticancer, can cause idiosyncratic pulmonary and hepatic toxicities that are associated with the reactive electrophile bioactivated by Cytochrome P450s (P450s). Until now, neither has the electrophilic intermediate been caught experimentally, nor has the subtle mechanism been declared. Herein, the underlying mechanism of bioactivation me...

Journal: :physical chemistry research 0
elham barani ferdowsi university of mashhad mohammad izadyar ferdowsi university of mashhad mohammad reza housaindokht ferdowsi university of mashhad

in this study, functionalized β-cyclodextrin (β-cd) by aldehyde group was investigated as an oxidase enzyme mimic for the amino phenol oxidation. all calculations were performed by gaussian 09 package using two layers oniom method at the oniom (mpw1pw91/6-311++g(d,p)/uff) level. in the first step, h2o2 is encapsulated in the hydrophobic cavity. in the second step, h2o2 molecule oxidized the ald...

Journal: :European Journal of Organic Chemistry 2021

Abstract A highly diastereo‐ and enantioselective Mannich reaction of α ‐acetoxy‐ β ‐keto esters with isatin imine was developed. The quinine thiourea organocatalyst smoothly promoted the asymmetric to furnish various 3‐substituted‐3‐aminooxindole derivatives bearing two adjacent tetra‐substituted stereocenters in up 93 % yield, 98 ee >20 : 1 dr . transition state structure absolute configur...

Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...

Journal: :Chemical communications 2015
Cláudio M Nunes Igor Reva Rui Fausto Didier Bégué Curt Wentrup

We discovered a 1,3-dipolar species co-existing in two different structures. Photolysis of matrix-isolated 5-phenyltetrazole generates two forms of phenylnitrile imine: propargylic and allenic. They are not resonance structures but correspond to different energy minima, representing bond-shift isomers. These distinct species were characterized spectroscopically and confirmed by calculations up ...

Journal: :Chemical science 2015
Chong Liu Jian-Hua Xie Gui-Long Tian Wei Li Qi-Lin Zhou

A new iridium catalyst containing an imine-diphosphine ligand has been developed, which showed high efficiency for the hydrogenation of CO2 to formate (yield up to 99%, TON up to 450 000). A possible catalytic mechanism is proposed, in which the imine group of the catalyst plays a key role in the cleavage of H2 and the activation of CO2.

Journal: :Indian Journal of Pharmaceutical Education and Research 2023

Abstract: Introduction: Smoking is the primary cause of Chronic obstructive pulmonary disease (COPD) leading to alarming increase in worldwide death. Cigarette smoking a dangerous risk factor causing mucosal inflammation and lung damage caused by nicotine, which more addictive than other narcotics. This study was undertaken assess potential quinine ameliorating cigarette smoke extract (CSE) ind...

Journal: :iranian journal of pharmaceutical research 0
akbar mobinikhaledi arak university- org. chem naser foroughifar azad university/arak university tahere mosleh arak university ahmad hamta arak university/biology dept

abstractpyrimidine nucleosides are constituents of fundamental structure of the cells. there has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه ایلام - دانشکده علوم پایه 1393

سولفوکسیدها حدواسط های سنتزی مفیدی در سنتز مولکولهای مهم شیمیایی و بیولوژیکی محسوب می شوند. روش اصلی برای ساخت سولفوکسید ها، اکسید کردن سولفید های مربوطه است.به همین دلیل در این پایان نامه از دوکاتالیزگر مزوپروس برای اکسایش شیمی گزین سولفید ها به سولفوکسید ها استفاده شده است.در بخش اول این پایان نامه zr-imine-mcm-41 و در بخش دوم zr-imine-mcm-48 آماده گردید و به عنوان کاتالیزگرهای قابل بازیافت ب...

ژورنال: طب مکمل 2017
جعفری منش, هادی, حاجی آقایی, رضا, حسن بیگ, محمدمهدی, رنجبران, مهدی, صادقی, هاجر, علیمرادیان, عباس, محرابی, فاطمه,

Introduction: Pain relief during routine procedures such as inserting IV or intravenous treatment is affected patient satisfaction of care. The aim of this study was to evaluate comparative effects of quinine plant and lidocaine on pain of venipuncture respectively. Methods: This study was an interventional study in 1394. Samples were selected by convenience sampling from patients referred t...

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