نتایج جستجو برای: radiation lethality
تعداد نتایج: 248735 فیلتر نتایج به سال:
WR-2721 (ethiofos) is a promising protector against radiation-induced lethality and may be useful in cancer radiotherapy (Davidson et al . , 1980). However, ethiofos also produces nausea, vomiting, diarrhea, and hypotension, which implies severe behavioral consequences (Bogo et al . , 1985). We studied the effects of ethiofos on behavior in monkeys and its ability to mitigate early transient in...
The radioprotective capacity of a rationally-designed Mn2+-decapeptide complex (MDP), based on Mn antioxidants in the bacterium Deinococcus radiodurans, was investigated in a mouse model of radiation injury. MDP was previously reported to be extraordinarily radioprotective of proteins in the setting of vaccine development. The peptide-component (DEHGTAVMLK) of MDP applied here was selected from...
These studies define a new mechanism-based approach to radiosensitize tumor cure by single dose radiotherapy (SDRT). Published evidence indicates that SDRT induces acute microvascular endothelial apoptosis initiated via acid sphingomyelinase (ASMase) translocation to the external plasma membrane. Ensuing microvascular damage regulates radiation lethality of tumor stem cell clonogens to effect t...
Hydroferrate fluid, MRN-100, an iron-based compound derived from bivalent and trivalent ferrates, is a potent antioxidant compound. Therefore, we examined the protective effect of MRN-100 against γ-radiation-induced lethality and damage to hematopoietic tissues in fish. A total of 216 Nile tilapia fish (Oreochromis niloticus) were randomly divided into four groups. Group 1 served as a control t...
The ecocentric strategy of radiation protection involves the expansion experimental bases radiation-induced effects in representatives biota. In this article we studied change relevant indicator (mortality) terrestrial mollusk F. fruticum M. after gamma-irradiation with doses from 10 to 300 Gy. is not yet included list reference species, but it meets requirements ICRP for organisms. aim work es...
Proliferating cells of the external granular layer (EGL) in the developing cerebellum are highly sensitive to ionizing radiation. We examined the effect of lithium, an inhibitor of intracellular signaling, on the manifestation of radiation-induced apoptosis. Newborn mice were exposed to 0.5 Gy gamma-irradiation alone, or first were treated with lithium (10 mumol/g, SC) then given 0.5 Gy irradia...
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