Backgrounds: Bleomycin (BLM) has been labeled with radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [62Zn] zinc chloride for oncologic PET studies. Materials and methods: The complex was obtained at the pH=2 in normal saline at 90 ° C in 60 min. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). Stability of complex ...

Abstract The radiochemical effects of thermal neutron capture in tris(2,2,6,6-tetramethyl-3,5-heptandionato)chromium(III) (Cr(tmhd) 3 ) were investigated. A method was devised to quantify the amount induced 51 Cr activity recoverable original chemical form and confirm that it is indeed Cr(tmhd) . based on a combination separation (column chromatography recrystallization) analytical (radio-TLC, ...

Abstract A semi-automated purification module for the cyclic separation of 99m Tc was designed production [ Tc]TcO 4 – from ? irradiated 100 Mo target. The process carried out by using a 3-column system and final product, , obtained in total volume 7 mL. To confirm proper achieved Tc, radio-labeling procedure DTPA chelator performed. radiochemical purity higher than 95%, which meets strict radi...

Introduction: Auger electron based radioimmunotherapy (RIT) using 111In-DOTA-trastuzumab (111In-DOTA-antiHer2) feasibility was studied in vitro on a HER2/neu positive cell line, SkBr3. Methods:111In-DOTA-antiHer2 was prepared according to the optimized conditions followed by quality control tests including radioch...

Background: In this study, human absorbed dose of a newly introduced bone imaging agent, 68Ga-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (68Ga-BPAMD), was estimated based on the rats data. Materials and Methods: 68Ga was obtained from the 68Ge/68Ga generator and it's radionuclidic and radiochemical purities were investigate...

At the "Radiochemistry Laboratory" of Accelerators and Applied Superconductivity Laboratory, LASA, several production and quality assurance methods for short-lived and high specific activity radionuclides, have been developed. Presently, the irradiations are carried out at the Scanditronix MC40 cyclotron (K=38; p, d, He-4 and He3) of JRC-Ispra, Italy, of the European Community, while both chemi...

   Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obt...

Background: Copper-64 (T1/2=12.7 h) is an important radionuclide used both in PET imaging and therapy. [64Cu]-pyruvaldehyde-bis (N4-methylthiosemicarbazone) ([64Cu]-PTSM) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). The wide range of 64Cu applications arouse great interest for its production. Materials and Methods: Cu-64...