UNLABELLED The purpose of this investigation was to develop and evaluate a new and rapid miniaturized chromatography system that would accurately assess the radiochemical purity of 99mTc-tetrofosmin without the problems of solvent ratios and time requirements associated with the manufacturer's recommended procedure. METHODS The migration of the radiochemical components of 99mTc-tetrofosmin wa...

Objective: Technetium-99m-sestamibi (-1"'Tc-MIBI) is a radiopharmaceutical imaging agent useful for assessing myocardial perfusion. We present a simple, rapid and accurate SepPak® method to confirm the radiochemical purity of "'Tc-MIBI. Methods: Technetium-99m-MIBI preparations of high (>95%), intermediate (83-90%) and low (25-43%) radiochemical purity were evaluated by the recommended thinlaye...

Chromatographic quality control testing of radioiodinated monoclonal antibodies (WJ MOAB) is necessary to assess radiochemical purity prior to patient injection. Conventional gel exclusion chromatography column scanning (GCS) is time consuming and not practical. We investigated rapid miniaturized chromatographic procedures for evaluating the radiochemical purity of 1311 MOAB. Three systems were...

Because radiopharmaceuticals are intended for human administration, quality control procedures are essential in ensuring the safety of these preparations. Although extensive quality control procedures are performed by the manufacturer, many radiopharmaceutical preparations are prepared in nuclear medicine departments using kits and short-lived radionuclides including technetium-99m CmTc) and in...

Good radiochemical purity of hippuran is important regarding the patient's radiation dose, primarily because of the high thyroid exposure from free iodide. The radiochemical purity and in vitro stability of 11 commercially available 131I, 125I, and 123I hippurans were analyzed by means of thin layer chromatography. Three different radioactive impurities were found in all hippuran samples: (a) f...

introduction: using labeled peptides enjoys high importance in nuclear medicine. somatostatin analogs labeled with different radionuclide are vastly investigated for diagnosis or treatment of somatostatin receptor positive tumors. labeling somatostatin analogs with 99mtc as alternative of 111in needs doing different quality control method for determination of labeling yield and complex stabilit...

introduction: the mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. the effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. to further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14c] clozapine with suitable ra...

Introduction: The mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. The effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. To further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14C] clozapine with suita...

OBJECTIVE The recommended method for radiochemical purity testing of 99mTc-mertiatide involves the use of a C-18 solid-phase mini-column cartridge. The mertiatide package insert states that the solvents should be "pushed through the cartridge slowly," but a flow rate is not specified. The mini-column cartridge instruction sheet recommends flow rates of 5-10 and 2-10 mL/min for conditioning and ...