نتایج جستجو برای: rat model of alzheimer
تعداد نتایج: 21390924 فیلتر نتایج به سال:
Imaging biomarkers are frequently proposed as endpoints for clinical trials targeting brain amyloidosis in Alzheimer's disease (AD); however, the specific impact of amyloid-β (Aβ) aggregation on biomarker abnormalities remains elusive in AD. Using the McGill-R-Thy1-APP transgenic rat as a model of selective Aβ pathology, we characterized the longitudinal progression of abnormalities in biomarke...
PURPOSE Alzheimer's disease (AD) results in memory impairment and neuronal cell death in the brain. Previous studies demonstrated that intracerebroventricular administration of streptozotocin (STZ) induces pathological and behavioral alterations similar to those observed in AD. Agmatine (Agm) has been shown to exert neuroprotective effects in central nervous system disorders. In this study, we ...
the geopolitics of afghanistan after september 11, 2001, and its impact on iranian national security
abstract u.s. attack to afghanistan after 9/11 provided opportunities for us who tried to become the dominant power after collapse of ussr and bipolar world. thinkers like fukuyama believed american liberal democrats thought would be universally accepted without resistances. liberal democracy is the best and final model of governance; in this regard, united state has moral responsibilities for...
objective(s): the effects of curcuma longa (c. longa) and curcumin on total and differential wbc count and oxidant, antioxidant biomarkers, in rat model of asthma were evaluated. materials and methods: total and differential wbc count in the blood, no2, no3, mda, sod, cat and thiol levels in serum were examined in control, asthma, asthmatic rats treated with c. longa (0.75, 1.50, and 3.00 mg/ml...
background: radiation-induced lung injury is a refractory side effect in lung cancer radiotherapy, the mechanism still remains unclear, hence an appropriate animal mode may become useful to investigate it. materials and methods: 50 female wistar rats were randomly divided into 5 groups, average 10 rats/cage: a. control group b. 3gy×10f c. 6gy×5f d. 12.5gy×1f e.15.3gy×1f. by different doses of r...
چکیده توان بالقوه تجاری سلولازها و کاربردهای گوناگون آن ها در بسیاری از صنایع انگیزه ای قوی برای تحقیق در این زمینه طی چند دهه گذشته بوده است. با توجه به کاربردهای فراوان این آنزیم در صنایع غذایی? در این پژوهش تصمیم به جداسازی ریزسازواره های تولید کننده سلولاز از خاک درختان انار، انگور، خرمالو و گردو حیاط دانشکده کشاورزی تربیت مدرس، گرفته شد. در این بین خاک درخت خرمالو به دلیل دارا بودن تعداد ...
BACKGROUND Possible mechanisms of Alzheimer Disease (AD) such as inflammation and oxidative stresses in the brain led us to investigate potential AD therapeutics of Melilotus officinalis, an herbal extract, with possible role as an anti-inflammatory and anti-oxidant agent. Among different genes which had important role in Sporadic AD (SAD), three genes including DAXX, NFkB and VEGF have shown s...
because of the huge amounts of proteomic data and demand for new methods of laboratory analysis results, proteins collective analysis, in addition to taking less time, biostatistician assist at identification of new patterns in the data set. in this study, rat hippocampus proteome in normal and alzheimer's disease (ad) were analyzed by using proteomic techniques and bioinformatics’ analysis. pr...
Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat mod...
Introduction: Olibanum improves memory in different models of learning. However, the effect of olibanum on models of Alzheimer’s disease has been less studied. In the present study, the effect of olibanum on memory in normal rats and in a rat model of Alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. Methods: Rats received an aqueous extract of...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید