some animal models have been used to study alzheimer's disease (ad). ad is an irreversible progressive neurodegenerative disease and the most common cause of dementia. animal studies have shown that there is a relation between decrease in cholinergic functions in the nucleus basalis of meynert (nbm) and loss of learning capability and memory. the aim of this study was to investigate the ef...

objective(s): intracerebral injection of bone marrow stromal cells (bmscs) is being investigated as a therapeutic tool to prevent alzheimer's disease (ad). our aim was to investigate the effects of bmscs by intrathecal injection in ad rat model. materials and methods: bmscs were obtained from the bone marrow of wistar rat and transplanted into ad rat model via intrathecal injection. the ra...

Objectives: This study evaluates the effects of 8 weeks of resistance exercises on the expression of neurotrophins and Trk receptors in Alzheimer model male Wistar rats. Methods: For this purpose, 32 mature male Wistar rats with a mean weight of 230-280 g were chosen and divided into Alzheimer and Sham groups. The rats in the sham group received normal saline, while the ones in the Alzheimer g...

Hesperetin (Hst) is a well-known bioflavonoid, has low bioavailability. Hesperetin nanoparticles (Nano-Hst) enhance its bioavailability. Nano-Hst were not explored for their potential therapeutic activities in Alzheimer’s disease (AD). Hence, the present study was performed to evaluate the protective effect of Nano-Hst in comparison to free Hesperetin on against intracerebroventricular in...

introduction: intracerebroventricular (i.c.v.) injection of streptozotocin (stz) to rodents has been reported as an appropriate model for sporadic dementia of alzheimer's type (sdat), characterized by a progressive impairment of memory. however, very little or nothing is known about non-cognitive behavioral effects in the stz model. this study was carried out in order to show the protectiv...