background: prostate cancer is one of the most widespread cancers in men and is fundamentally a genetic disease. identifying regulators in cancer using novel systems biology approaches will potentially lead to new insight into this disease. it was sought to address this by inferring gene regulatory networks (grns). moreover, dynamical analysis of grns can explain how regulators change among dif...

background in many parts of the world, ongoing deficiencies in health systems compromise the delivery of health interventions. the world health organization (who) identified four functions that health systems need to perform to achieve their goals: efforts to strengthen health systems focus on the way these functions are carried out. while a number of studies on health systems functions have be...

conclusions the changes of treg and th17 cells and their associated cytokines were related to virological and biochemical responses. results in complete and partial-responders, treg cells frequencies and il-10, tgf-β1, il-23 levels were all decreased significantly after na therapy, while th17 cells and the il-17 levels were increased slightly. treg/th17 ratio was only dramatically declined in c...

background: regulatory t cells (tregs) have been involved in impaired immunity and may have a pivotal role in persistence of viral infections. objective: to develop a simple and reliable in-house three color flow cytometery of peripheral blood to understand the role of hcv infection in the increase of tregs. methods: the level of naturally occurring cd4+cd25+foxp3+ regulatory t cells (ntregs) i...

signal regulatory proteins (sirp) belong to immunoglobulin super family (igsf) and relate to integrin signaling cascades. it has been shown that sirpa is expressed in a variety of cells including myeloid cells and neurons. in the present study the expression of this igsf member in articular chondrocytes was investigated. methods: using a panel of anti-sirpalpha antibodies, immunohistochemistry,...

immune thrombocytopenic  purpura (itp) is an autoimmune bleeding disorder characterized by production  of auto-antibodies against platelet antigens. it is obvious that regulatory t cells (tregs) have a major role in controlling immune homeostasis and preventing autoimmunity. to investigate the frequency and functions of tregs, twenty itp patients and twenty age- and sex- matched healthy control...

abstract background and aims: vitamins are essential constituents of our diet that longley have been known to influence the immune system. vitamin d3 and b9 have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. 1, 25(oh)2d3 metabolizing enzymes and vitamin d receptor (vdr) are present in many cell ty...

This paper analyzes several emerging transnational regulatory systems that engage, but are not centered on state legal systems. Driven primarily by civil society organizations, the new regulatory systems use conventional technical standard setting and certification techniques to establish market-leveraged, social and environmental regulatory programs. These programs resemble state regulatory pr...