Methods. Serial tangential sections and whole-mount preparations of the scleral spur region of 18 human eyes of different ages were investigated with electronmicroscopic and immunohistochemical methods. For immunohistochemistry antibodies against neurofilament-proteins, synaptophysin, substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), neuropeptide...

Background and Aims: The prevalence of latent autoimmune diabetes in adults (LADA) among diabetic patients is less recognized and underdiagnosed. The aim of this study was to determine the prevalence of LADA in type 2 diabetic patients and to compare the characteristics of these two groups in Torbat-e Heydarieh, Iran. Materials and Methods: Totally, 198 male and 277 female patients diagnosed ...

Scorpion venom is the richest source of peptide toxins with high levels of specific interactions with different ion-channel membrane proteins. The present study involved the amplification and sequencing of a 310-bp cDNA fragment encoding a beta-like neurotoxin active on sodium ion-channel from the venom glands of scorpion Androctonus crassicauda belonging to the Buthidae family using r...

BACKGROUND/OBJECTIVES: The aim of this study was to investigate the effect of Berberis vulgaris (BV) juice consumption on insulin homeostasis, glycemic profiles of patients with benign breast disease (BBD). SUBJECTS/METHODS: This parallel design, triple-blind, randomized and placebo controlled clinical trial was conducted on 85 eligible women diagnosed with BBD who recruited from Nour-Nejat hos...

Galanin receptors (provisional nomenclature as recommended by NC-IUPHAR [57]) are activated the endogenous peptides galanin and galanin-like peptide. Human is a 30 amino-acid non-amidated peptide [52]; in other species, it 29 amino acids long C-terminally amidated. Amino 1-14 of highly conserved mammals, birds, reptiles, amphibia fish. Shorter species (e.g. human galanin-1-19 [21] porcine galan...

Galanin receptors (provisional nomenclature as recommended by NC-IUPHAR [57]) are activated the endogenous peptides galanin and galanin-like peptide. Human is a 30 amino-acid non-amidated peptide [52]; in other species, it 29 amino acids long C-terminally amidated. Amino 1-14 of highly conserved mammals, birds, reptiles, amphibia fish. Shorter species (e.g. human galanin-1-19 [21] porcine galan...

The purpose of this study was to optimize a method for the encapsulation of P5 peptide, a new designed peptide containing MHC class I epitopes from rat HER2/neu protein, into liposomes as an approach for breast cancer vaccine formulation. The efficiency of liposomal encapsulation of peptides is generally low and development of an optimized method to increase encapsulation efficiency is a big ch...

Parathyroid hormone-related peptide (PTHrP) was originally isolated as a causal factor for hypercalcemia of malignancy (HM), one of the most frequent paraneoplastic syndromes. The association of hypercalcemia with malignancy was originally assumed to be the result of tumor invasion of bone with resultant osteolysis (1,2), but subsequent studies demonstrated an association of hypercalcemia with ...