The reproducibility of activation patterns in the whole brain obtained by functional magnetic resonance imaging (fMRI) experiments at 4 Tesla was studied with a simple finger-opposition task. Six subjects performed three runs in one session, and each run was analyzed separately with the t-test as a univariate method and Fisher's linear discriminant analysis as a multivariate method. Detrending ...

BACKGROUND A number of gene-profiling methodologies have been applied to microRNA research. The diversity of the platforms and analytical methods makes the comparison and integration of cross-platform microRNA profiling data challenging. In this study, we systematically analyze three representative microRNA profiling platforms: Locked Nucleic Acid (LNA) microarray, beads array, and TaqMan quant...

Objective(s):  Denaturing high performance liquid chromatography (DHPLC) is a high throughput approach for screening DNA sequence variations. To assess oven calibration, cartridge performance, buffer composition and stability, the WAVE Low and High Range Mutation Standards are employed to ensure reproducibility and accuracy of the chromatographic analysis. The purpose of this study was to provi...

Introduction Application of quality control (QC) programs at diagnostic radiology departments is of great significance for optimization of image quality and reduction of patient dose. The main objective of this study was to perform QC tests on stationary radiographic X-ray machines, installed in 14 hospitals of Kerman province, Iran. Materials and Methods In this cross-sectional study, QC tests...

• Accuracy. Result is not identical to that of a previous run of the same job, or does not fall within valid range. • Performance. Observe a performance difference from a previous run of the same job. • Portability. Can’t execute the same job on a distinct software stack, platform, or compute site. • Longevity. Unable to reproduce a result due to lack of identical resources as previous run of t...

pressure and inter-beat interval variability in man. Apart from that the topic of the study is interesting and important, the paper contains some terminological inconsistencies which seriously undermine implications of research and thus, credibility of the conclusions made by the Authors. It is not uncommon to find studies with inconsistent terminology and definitions, with some terms being def...

M elanoma is associated with DNA damage and genomic alterations caused by ultraviolet light. In 2012, as part of efforts to better understand the causes of melanoma, researchers at the Broad Institute, the Dana-Farber Cancer Institute and a number of other institutes reported the results of whole genome sequencing of 25 human metastatic melanomas (Berger et al., 2012). This analysis discovered ...

Two papers were selected this year for their implementation of novel analytical approaches on archived data provided by the Dartmouth fMRI Data Center. Coincidentally, the two independent studies, conducted in different parts of the world, tested their models on the same data set, originally collected by Ishai, Ungerleider, Martin, Schouten, and Haxby (1999) and Ishai, Ungerleider, Martin, and ...

The reproducibility of a method of measuring rectal distensibility by continuous controlled fluid inflation with a balloon has been evaluated in 15 patients. The volume at sensation threshold, constant sensation and maximal tolerance, the pressures at these volumes and rectal compliance were measured. The mean coefficients of variation of the seven variables measured ranged from 4.7%-7.9%. The ...