The incidence of cardiac rupture complicating myocardial infarction has declined since the introduction of thrombolytic therapy. Despite the advances in the management of myocardial infarction, cardiac rupture remains an important cause of death among infarction-related fatalities. We discuss a patient who presented to our hospital with myocardial infarction and who subsequently developed a com...

Senescence is a recognized mechanism of cardiovascular diseases; however, its contribution to myocardial fibrosis and rupture after infarction and the underlying mechanisms remain unclear. Here we showed that senescent cardiac fibroblasts markedly accumulated in heart after myocardial infarction. The expression of key senescence regulators, especially p53, was significantly up-regulated in the ...

are rare cardiac abnormalities. They are dilatations of the aortic sinuses and are classified as congenital or acquired. Sometimes they coexist with other congenital heart diseases and they often rupture into the heart chambers causing acute clinical syndrome. ASVs and coexisting congenital heart disease can easily be diagnosed with echocardiography. Early diagnosis and immediate surgical treat...

Inadequate healing of myocardial infarction may contribute to local expansion of the infarct, frequently leading to chamber dilation, heart failure, or myocardial rupture. Experimental evidence in mouse models suggests that Factor XIII might play a key role in wound healing, and low persistent values lead to increased incidence of cardiac rupture following myocardial infarction. Here we would l...

conclusion results reinforced the pivotal role of vascular geometry, with respect to hemodynamics, together with the importance of performing patient-specific cfd analyses, through which the effect of different blood flow conditions on the aneurysm hemodynamics could be evaluated. objectives this study aimed to investigate the effects of variations in heart rate and internal carotid artery (ica...