In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...

glucocorticoid steroids are widely used as anti-inflammatory and immunosuppressive medications and are well known to induce osteoporosis. in present study 24 rats were randomly divided into four groups (n=6): group a (control), group b (sham)that was treated only by normal saline for 1 month.group c that was treated by methylprednisolone acetate alone (0.2 mg/kg) for 1 month. group d that was t...

conjugated linoleic acids (cla) are natural constituents of meat and dairy products from ruminants, originating from bacterial biohydrogenation in the rumen. cla supplementation increases the health benefits of animal-derived foods. there are inconsistent reports of the effects of dietary cla on chicken’s performance; however, the majority of previous reports cite anti-lipogenic effects of cla....

understanding cattle metabolism and its relationship with milk products is important in bovine breeding. a systemic view could lead to consequences that will result in a better understanding of existing concepts. topological indices and quantitative characterizations mostly result from the application of graph theory on biological data. in the present work, the enzyme network involved in cattle...

it is well-known that deficiency or over exposure to various elements has noticeable effects on human health. the effect of an element is determined by several characteristics, including absorption, metabolism, and degree of interaction with physiological processes. iron is an essential element for almost all living organisms as it participates in a wide variety of metabolic processes, includin...

heat stress is a significant occupational health and safety for workers in petrochemical industries. heat stress is a combination of heat load individual and environmental factors impose on workers’ bodies, which in turn, have impacts on workers’ performance, safety, and health. the present paper is carried out to determine the heat stress levels in workplace and to compare it with allowed wet ...

imatinib is an orally administered tyrosine kinase inhibitor which inhibits the bcr-abl protein-tyrosine kinase with high selectivity. imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. the metabolism of imatinib is mediated by the cytochrome p450 (cyp) isoenzymes in the liver and gut wall. cgp74588 is a major active metabolite of ima...

Voriconazole is a potent second-generation triazole antifungal agent with broad-spectrum activity against clinically important fungi. It is cleared predominantly via metabolism in all species tested including humans. N-Oxidation of the fluoropyrimidine ring, its hydroxylation, and hydroxylation of the adjacent methyl group are the known pathways of voriconazole oxidative metabolism, with the N-...