Background and Objective: Epilepsy is a long-lasting central nervous system disorder that is accompany with spontaneous seizures and insufficiency in learning and memory. Now drug treatment is the most common therapy but some patients do not research to suitable control of their seizures with current drugs. Hence, new treatment is needed to help those patients that are unaffected to existing dr...

Neurology® 2011;77:1 Seizures are one of the most common complications of stroke.1,2 Overall, 5%–15% of stroke patients will experience a seizure within 2 years of stroke. The reported risk factors for and incidence of seizures after stroke vary widely, likely secondary to differences in study design, study populations, and use of antiepileptic drugs (AEDs). In previous studies, the main risk f...

Seizures are a common presenting manifestation in children with disorders of amino acid metabolism. However, seizures may be very common in some specific diseases, but are rare in other diseases. In patients with classical maple syrup urine disease (MSUD), seizures commonly occur in the neonatal stage. But in intermittent or intermediate MSUD, seizures may develop in a later stage, or are uncom...

This paper critically reviews the current literature and evidence on diagnosis, classification, clinical approach, management of neonatal seizures. A stepwise approach for treatment seizures is presented. In a recent randomized controlled trial comparing phenobarbital to levetiracetam as first-choice anti-seizure medication with primary outcome seizure free 24 h, former was found superior (80% ...

A 31-year-old pregnant woman presented with headache, fever and left-sided focal motor seizures, which progressed to bilateral tonic-clonic seizures. Her medical history included Crohn's disease treated azathioprine adalimumab, were discontinued when she became pregnant. cerebro-spinal fluid was entirely normal viral PCR negative. Extensive testing for infectious, autoimmune or malignant causes...

OBJECTIVE To assess the frequency, characteristics, and risk of injury during seizure attacks. DESIGN Questionnaire survey. SETTING Epilepsy out-patient clinic of the National Hospital for Neurology and Neurosurgery, Institute of Neurology, London. PATIENTS One hundred consecutive epileptic patients and their caretakers or relatives, who attended the hospital between 1 May and 30 June 200...

Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world.Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In thispaper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3,5-dicarboxamides was performed.Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylenetetr...

PURPOSE Seizures are a common manifestation of many diseases and play an important role in the clinical presentation and quality of life (QOL) in patients with gliomas. The purpose of the present study was to investigate the possible correlation between tumor-related seizures and clinicopathological factors that influence preoperative seizure characteristics and relevant survival outcomes. ME...

background: an important role for oxidative stress, as a consequence of epileptic seizures, has been suggested. coriandrum sativum has been shown that have antioxidant effects. central nervous system depressant effects of c. sativum have also been reported. in this study, the effects of hydroalcoholic extract of aerial parts of the plants on brain tissues oxidative damages following seizures in...

objective 1-3% of the population suffer from epilepsy. up to 30% of them develop refractory epilepsy and their seizures occur more than once per month despite receiving at least 2 first line antiepileptic drugs. in  this group, more efficacious antiepileptics are needed. this study was undertaken to evaluate the efficacy and safety of oxcarbazepine as an adjunction therapy in children with refr...