Escherichia coli is an important zoonotic pathogen causing intestinal diseases. In recent years, due to the unreasonable use of antibiotics, drug resistance bacteria has been increasing, and proportion multi-drug resistant strains also rising, which directly threatens health animals humans. The antimicrobial peptide MPX was isolated from wasp venom had better antibacterial activity against Gram...

An allelic variant of protein tyrosine phosphatase nonreceptor type 22 (PTPN22), PTPN22(R620W), is strongly associated with type 1 diabetes (T1D) in humans and increases the risk of T1D by two- to fourfold. The NOD mouse is a spontaneous T1D model that shares with humans many genetic pathways contributing to T1D. We hypothesized that the introduction of the murine orthologous Ptpn22(R619W) muta...

Purpose: To study the influence of berberine on endocrine status in mice with polycystic ovary syndrome (PCOS), and underlying mechanism action.
 Methods: A total 80 were used this research. Sixteen randomly selected to serve as control. The remaining 64 subcutaneously given dehydroepiandrosterone (DHEA) injection establish a mouse model PCOS. PCOS divided into group, low-dose-, medium-dos...

Increased risks of skeletal fractures are common in patients with impaired glucose handling and type 2 diabetes mellitus (T2DM). The pathogenesis fragility these remains ill-defined as present normal to high bone mineral density. With increasing cases intolerance T2DM it is imperative that we develop an accurate rodent model for further investigation. We hypothesized a fat diet (60%) administer...

I find introspection to be painful. Looking back, I recall doing little of it before age sixteen. Instead, I mainly did the things that I was instructed to do. I studied hard and performed well in courses and examinations, for no deeper reason than that this was what one was supposed to do. As an adult I have introspected when it has seemed constructive to do so, but I still try not to overdo i...

P. 3 Is there a zombie nation in our future? A continual humans vs. zombies battle would make for an entertaining school day, don't you think? AftE '*WI$r' p. 10 It might put you in a Wyrd funk Rice Players' Wyrd Sisters misfires on a number of dramatic levels. But that Hwel guy sure is good. SPORTS P. 14 Jazzing it up Go behind the scenes with former Rice basketballer Morris Almond, as he talk...

Deoxyguanosine kinase (dGK) is a nuclear gene product that catalyzes the phosphorylation of purine deoxyribonucleosides and their analogues. The human enzyme is located predominantly in the mitochondria, as shown by biochemical fractionation studies and in situ localization of the overexpressed recombinant protein. Here we describe the cloning of mouse dGK cDNA and the identification of a novel...

RPS4Y, a Y-linked gene in humans, appears to encode an isoform of ribosomal protein S4. A homologous locus on the human X chromosome, RPS4X, lies close to the X-inactivation center but fails to undergo X-inactivation. We have isolated a genomic clone from the mouse Rps4 locus, the homolog of human RPS4X. We derived an intron probe that hybridizes to the functional Rps4 locus but does not cross-...

Lipid droplet proteins of the PAT (perilipin, adipophilin, and TIP47) family regulate cellular neutral lipid stores. We have studied a new member of this family, PAT-1, and found that it is expressed in highly oxidative tissues. We refer to this protein as "OXPAT." Physiologic lipid loading of mouse liver by fasting enriches OXPAT in the lipid droplet tissue fraction. OXPAT resides on lipid dro...