Emerging T-helper type 2 (Th2 ) cytokine-based asthma therapies, such as tralokinumab, lebrikizumab (anti-interleukin (IL)-13), and mepolizumab (anti-IL-5), have shown differences in their blood eosinophil (EOS) response. To better understand these effects, we developed a mathematical model of EOS dynamics. For the anti-IL-13 therapies, lebrikizumab and tralokinumab, the model predicted an incr...

Electrical overstress, or EOS, is a phenomenon where electrical signals applied to a circuit or a device exceed normal operating parameters. These excessive electrical signals are abnormal by definition and are not a part of normal operation of the devices. According to Intel1 , EOS is the number one cause of damage to IC components. In the broadest terms, EOS also includes electrostatic discha...

A hybrid statistical mechanical model, which is fully consistent with the bulk perturbed-chain statistical associating fluid theory (PC-SAFT) in describing properties of fluids, was developed by coupling density functional theory with PC-SAFT for the description of the inhomogeneous behavior of real chain molecules in nanopores. In the developed model, the modified fundamental measure theory wa...

We generate a second equation of state (EOS) of nuclear matter for a wide range of temperatures, densities, and proton fractions for use in supernovae, neutron star mergers, and black hole formation simulations. We employ full relativistic mean field (RMF) calculations for matter at intermediate density and high density, and the virial expansion of a nonideal gas for matter at low density. For ...

Materials issues are a key concern for the existing nuclear reactor fleet in the United States as material degradation can lead to increased maintenance, increased downtime, and increased risk. Extending reactor life to 60 years and beyond will likely increase susceptibility and severity of both known and new forms of degradation. A multitude of concrete-based structures are typically part of a...

Herein, the application of Carnahan-Starling-vdW-β equation of state (EoS) for 13 refrigerant fluids was investigated. The EoS could predict the saturated liquid densities of these refrigerants over the temperature range of 100-400 K and pressures from zero up to187 MPa with the average absolute deviations of 2.66%. The accuracy of Carnahan-Starling-vdW-β EoS in liquid density prediction was al...

Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are members of the immunoglobulin superfamily adhesion molecules on vascular endothelium and important in the development of eosinophil (EOS) accumulation in allergic inflammation. To define the role of these adhesion proteins in EOS inflammation, peripheral blood EOS from allergic donors were incubated in...