A real-time, continuous optical particle separation method, termed cross-type optical particle separation, is investigated theoretically and experimentally. The trajectory of a particle subject to cross-type optical particle separation is predicted by solving the particle dynamic equation and compared with experimental data. For various flow velocities and particle sizes, the retention distance...

Asymmetrical Flow Field-Flow Fractionation (AF4) is a separation technique applicable to particles over a wide size range. Despite the many advantages of AF4, its adoption in routine particle analysis is somewhat limited by the large footprint of currently available separation cartridges, extended analysis times and significant solvent consumption. To address these issues, we describe the fabri...

Submicron separation is the segregation of particles having a diameter difference of less than one micrometre. We present an acoustofluidic particle separator with submicron separation resolution to study the continuous, label-free, and contactless separation of polystyrene (PS) particles based on their acoustofluidic parameters such as size, density, compressibility and shape. In this work, th...

Phase-separation fronts leave in their wakes morphologies that are substantially different from the morphologies formed in homogeneous phase separation. In this paper we focus on fronts in binary mixtures that are enslaved phase-separation fronts, i.e., fronts that follow in the wake of a control-parameter front. In the one-dimensional case, which is the focus of this paper, the formed morpholo...

The ability to separate and analyze chemical species with high resolution, sensitivity, and throughput is central to the development of microfluidics systems. Deterministic lateral displacement (DLD) is a continuous separation method based on the transport of species through an array of obstacles. In the case of force-driven DLD (f-DLD), size-based separation can be modelled effectively using a...

In this paper, the microfluidic size-separation technique pinched flow fractionation (PFF) is used to separate cancer cells from white blood cells (WBCs). The cells are separated at efficiencies above 90% for both cell types. Circulating tumor cells (CTCs) are found in the blood of cancer patients and can form new tumors. CTCs are rare cells in blood, but they are important for the understandin...

This paper attempts the well-known regularized gamma distribution function to represent the separation efficiency of particle segregation in gravity concentrators. The model has four parameters that are evaluated by a least square fit between the model estimate and the measured data. The model takes into account the bivariate effects of particle size and particle density to define the size-dens...

BACKGROUND AND OBJECTIVE Fetal erythroblasts in maternal circulation represent a valuable source of fetal cell material which can be obtained with non-invasive procedures that do not endanger the fetus. Physical separation techniques have been invaluable in the isolation and characterization of different cells. There are basically two principles that have been used most successfully: separation...