Forced degradation studies on glipizide are conducted under the conditions of hydrolysis, oxidation, photolysis, and dry heat. The solutions are subjected to liquid chromatographic (LC) investigations to establish the number of products formed in each condition. The degradation products are characterized through isolation and subsequent NMR, IR, and MS spectral analyses, or through LC-mass spec...

Mycorrhiza is a mutualistic association between zone surrounding the root [2]. Although a lack in growth fungi and higher plants [1]. Different types of mycorrhizae response to VA-fungi inoculation in unsterilized soil was occur, distinguished by their morphology and to a also recorded, this result has been attributed to the fact certain extent, in their physiology. These include the that nativ...

The purpose of study was to develop and characterize once daily extended release matrix tablets of Carbamazepine (CBZ), an antiepileptic drug. Tablets were prepared by wet granulation method. Methocel K15M CR and Methocel K100LV CR polymers were used as rate retarding agents in fourteen formulations. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compr...

Urethan, a potent teratogenic and carcinogenic agent in experimental animals, has been used in Japan for the past 25 years as a cosolvent of water-insoluble analgesic and sedative drugs. Urethan is used also as a solubilizer and cosolvent for pesticides, fumigants, and cosmetics, because it is a good solvent for various organic materials (6). In the past, urethan was used clinically as an antin...

BACKGROUND Nowadays, many cytotoxic anticancer drugs exhibit low solubility and poor tumor selectivity, which means that the drug formulation is very important. For example, in the case of paclitaxel (PTX), Cremophor EL(®) (BASF, Ludwigshafen, Germany) needs to be used as a solubilizer in its clinical formulation (Taxol(®), Bristol-Myers Squibb, New York, NY), although it can cause serious side...

The present study demonstrates the use of mixed co solvency in the enhancement of solubility and estimation of ketoprofen, practically water insoluble dug and thus precludes the use of organic solvents. The selected solubilizers were sodium citrate (15%), PEG 400 (8%) and polyvinyl pyrolidine (7%). Beer’s law was obeyed in the concentration range of 2-20μg/ml at wavelength of 256nm. The solubil...

The human epidermis is a common site for local and systemic delivery of medication. This study aims to compare the safety and toxicological profile of RheoSpray, a proprietary sprayable topical gel compounding base, to the profile of the positive control Triton X-100, using a 3D model of the human epidermis tissue. Results have demonstrated that RheoSpray presented an ET50 superior to 24 hr, as...

The animals used were inbred Hartley strain guinea pigs (400-500 g), inbred Sprague strain rats (300400 g), and a purebred Dutch rabbit (1,300 g). Lymphocytes were obtained from the guinea pig and rat lymph nodes and the rabbit spleen. The animals were anesthetized with ethyl ether and exsanguinated via caridac puncture. The blood was defibrinated, and the serum was collected and filtered throu...

BiofertiJizers are microbial preparations containing living cells of different microorganisms which have the ability to mobilize plant nutrients in soil from unusable to usable form through biological process. They are environmental friendly and play significant role in crop production. Previollsly it is mainly used for field crops but now-a-days it is used for fruit crops also. Biofertilizers ...

The disposition of mefloquine has been investigated in the isolated perfused rat liver (IPRL) preparation after the administration of [C]mefloquine HCI (3.8 mg, 4 1 Ci, quinoline ring labeled). Mefloquine underwent avid hepatic uptake within 10 min of dosing. Also at this point, hepatic oxygen consumption was reduced markedly in four of the six IPRL preparations, but was restored completely by ...