Urea is an effective solubilizer for dyes with low aqueous solubility. To establish, at a molecular level, the reason behind action of urea as solubilizer, we employ rigorous statistical thermodynamics approach based on Kirkwood-Buff theory solutions. We show that (i) contrary to classical hypothesis “water structure breaking”, effect dye hydration makes minor contribution solubilization; (ii) ...

meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic agent. the aim of the present work was to investigate the effect of different types of carriers on in vitro dissolution of meloxicam. meloxicam solid dispersions were prepared by physical mixing, co-grinding and solvent evaporation methods with polyethylene glycol (peg) 6000. the effect of solubilization by...

The most important constraint limiting crop yield in developing nations worldwide, and especially among resource-poor farmers, is soil infertility. Therefore, maintaining soil quality can reduce the problems of land degradation, decreasing soil fertility and rapidly declining production levels that occur in large parts of the world needing the basic principles of good farming practice. Minerals...

Bacillus sp. strain CPSM8 is an efficient solubilizer and mineralizer of phosphorus. Here, we present the 4.39-Mb draft genome sequence of the strain, providing insight into the phosphorus-releasing genes related to productivity in aquatic habitats.

Controlled porosity osmotic tablet of carvedilol phosphate prepared and evaluated in this study. Carvedilol phosphate is very low soluble drug. So it is difficult to formulate osmotic tablet of carvedilol phosphate which gives drug release up to 24 hr at zero order. To get desired dissolution profile various formulation parameters like osmogen concentration, level of weight gain and level of po...

A method for solubilization of pristine fullerene (C(60)) in water was proposed by directly using bovine serum albumin (BSA) as a "solubilizer" by means of the unfolding mechanism. C(60) aqueous solution with a small distribution size, excellent dispersion stability and high dispersion concentration was obtained without the use of derivatization and organic solvent.

Abstract The solubility graph $$\Gamma _S(G)$$ Γ S ( G ) associated with a finite group G is simple whose vertices are the elements of , and there an edge between two distinct if only they generat...

There is a need to develop dosage forms suitable for children improve drug treatment. Extemporaneous compounding of drugs one way meet these needs. However, excipients generally considered as safe in adults may not be appropriate intended children. The aim was optimize the composition two pediatric liquid preparations by substituting paraben microbiological preservative and ethanol solubilizer,...