Several lines of evidence have recently suggested that natural killer (NK) cells develop immunological memory against viral infections. However, there is no apparent evidence that NK cells acquire specific memory against Mycobacterium bovis bacillus Calmette-Guérin (BCG), the only currently licensed vaccine for preventing tuberculosis. In the present study, we investigated whether murine spleni...

Group 1 CD1 molecules have been shown to present lipid and glycolipid Ags of mycobacteria to human T cells. However, a suitable animal model for the investigation of this component of antimycobacterial immunity has not yet been established. Previously, we found that guinea pigs express multiple isoforms of group 1 CD1 proteins that are homologous to human CD1b and CD1c. In this study, we show t...

Epidermal growth factor (EGF) is a potent mitogen for a variety of eukaryotic cells. EGF is found in a number of tissues and is prevalent in necrotic tissues and granulomata. The biological effect of EGF on mammalian cells is initiated by the binding to a specific receptor. Both Mycobacterium avium and Mycobacterium tuberculosis cause lung infections and localized or disseminated disease in bot...

A 23 day old infant patient underwent 99mTc-denatured RBC scanning for locating possible ectopic spleen in our department.  The scan showed no tracer activity in normal splenic bed in the left upper quadrant and an ectopic spleen was shown on the right side of abdomen inferior to the liver. 99mTc-denatured RBC scan is an easy and available method for splenic localization i...

although splenic metastasis is fairly common in disseminated cancer, solitary splenic metastasis in the absence of diffuse dissemination is rare. we report a case of 44 year-old man who developed isolated splenic metastasis of colon cancer. the patient had undergone right sided hemicolectomy for colon cancer in 1988. in 2001, he underwent reoperation because of local recurrence of tumor in the ...

visceral leishmaniasis or kala azar is endemic in certain regions of india. in endemic areas, the con-stellation of fever, progressive weight loss, weakness, pronounced splenomegaly, anemia, leukopenia, and hypergammaglobulinemia is highly suggestive of visceral leishmaniasis. demonstration of the parasite in liver, splenic or bone marrow aspirates is confirmatory. we present a case in which le...

Splenic abscess is not a common condition and actinomyces as a cause is very rarely reported. We report a case of actinomycosis of spleen in a 12 year-old boy, with a few days history of abdominal pain and fever. Past medical history was not significant. Due to sever abdominal pain and tenderness condition laparatomy was done that a small perforated area was seen on hilum of spleen, so splenect...

Background: Splenic cysts are known as rare clinical encounter. Classifying into primary (true) and secondary cysts (pseudocysts), true cysts contain cellular epithelial lining and subdivided into parasitic and non-parasitic cysts. This study aimed to determine the outcome of treatment in patients with splenic cyst. Methods: All patients with splenic cyst who had been treated in Department o...