M protein is a major surface component of group A streptococci, and more than 80 distinct serological types exist . Antigenic variability resides in the NH2-terminal distal portion ofthe fibrillarM protein molecule, whereas the COOH-terminal half is highly conserved among different M serotypes (1, 2) . With few exceptions, only serum IgGdirected to the antigenically variable portion ofM protein...

OBJECTIVE The recommended dosing frequency of oral penicillin for the treatment of acute streptococcal tonsillopharyngitis has long been 3 to 4 times daily. In 1994, treatment guidelines included twice-daily (BID) dosing for the first time, a recommendation that could significantly increase the ease of compliance. This meta-analysis was performed to determine whether overall cure rates differed...

BACKGROUND The incidence and severity of invasive group A streptococcal infection demonstrate great variability over time, which at least, in part, seems to be related to group A streptococcal type distribution among the human population. METHODS An enhanced surveillance study of invasive group A streptococcal infection (746 isolates) was performed in Sweden from April 2002 through December 2...

BACKGROUND People with a history of rheumatic fever (RF) are at high risk of recurrent attacks and of developing rheumatic heart disease following a streptococcal throat infection. Giving penicillin to these people can prevent recurrent attacks of RF and subsequent rheumatic heart disease. However, there is no agreement on the most effective method of giving penicillin. OBJECTIVES To assess t...

Advancements in Case Studies Guttate Psoriasis Images, A Sign of Streptococcal Tonsillopharyngitis Ana Luísa Ribeiro1*, Carlos Magalhães Vieira1, Marta Pires Ribeiro1 and Santos2 1Family Medicine, ACeS Alto Tâmega e Barroso, Chaves, Portugal 2Family ULS Nordeste, Bragança, *Corresponding author: Ribeiro, UCSP Montalegre, Submission:January 13, 2023;Published: April 2023 DOI: 10.31031/AICS.2023....

Group A streptococcal (GAS) serology is used for the diagnosis of post-streptococcal diseases, such as acute rheumatic fever, and occasionally for the diagnosis of streptococcal pharyngitis. Experts recommend that the upper limits of normal for streptococcal serology be determined for individual populations because of differences in the epidemiology of GAS between populations. Therefore, we per...

INTRODUCTION The association of guttate psoriasis with a streptococcal throat infection and HLA-Cw*06 allele is well established in different populations. Nevertheless, only few studies on this form of disease have been performed in the Polish population. AIM To analyze the frequencies of streptococcal-induced guttate psoriasis and HLA-Cw*06 allele in 70 patients with guttate psoriasis origin...

It has been shown (Bernheimer & Ruffier, 1951 ) that physical disruption of streptococci belonging to Lancefield groups A, B, C and D results in the liberation of a substance which partially inhibits the depolymerizing action of group A streptococcal deoxyribonuclease. One of the striking characteristics of the inhibitory substance is its specificity, for although it inhibits the deoxyribonucle...

The importance of group A hemolytic streptococcal infections in the pathogenesis of rheumatic fever is widely recognized, but little is known of the mechanism by which the streptococcal infection gives rise to the disease. The concept that an antigen-antibody interaction may be involved in the origin of the pathologic processes has received increasing attention, and recent antibody studies (1, ...

The role lysogenic bacteriophage play in the pathogenesis of the host bacterium is poorly understood. In a previous study, we found that streptococcal coculture with human pharyngeal cells resulted in the induction of lysogenic bacteriophage as well as the phage-associated streptococcal pyrogenic exotoxin C (SpeC). In this study, we have determined that in addition to SpeC induction, a number o...