The radiation survival curves for the proliferative capacity of mammalian cells, both in vitro (1, 2) and in vivo (3, 4), are sigmoidal, suggesting that loss of proliferative capacity involves an accumulation of radiation damage. For mammalian cells in culture, Elkind and co-workers (5, 6) have demonstrated that accumulated sublethal damage may be rapidly repaired in surviving cells, by means o...

Resistance to phosphine fumigation in stored insects continues be challenging managing these pests worldwide. The role of detoxification enzymes metabolizing is yet explored fully. dose-response mortality against was assessed this study from six field populations Tribolium castaneum (Herbst) collected across India during 2021–23 at the Division Entomology, ICAR-Indian Agricultural Research Inst...

Laboratory bioassays were used to determine the efficacy of (S)-methoprene against 7 species of Australian mosquitoes. The 90% lethal concentration (LC90) ranged from 0.17 ppb for Aedes vigilax to 6.54 ppb for Culex sitiens. The survival of adults exposed as larvae to 2 sublethal dosages of (S)-methoprene was compared to a control group. Little effect was noted for Cx. sitiens and Culex annulir...

Human hematopoietic stem cell (HSC) xenotransplantation in NOD/SCID mice requires recipient conditioning, classically achieved by sublethal irradiation. Pretreatment with immunosuppressive and alkylating agents has been reported, but has not been rigorously tested against standard irradiation protocols. Here, we report that treatment of mice with a single dose (35 mg/kg) of Busilvex, an injecta...

A sublethal dose of x-rays was applied over the abdomen of rats and over the thorax for control purposes. 20 and 40 hours after radiation (i.e. during the "latent period") the rate of absorption of glucose, fructose and mannose was markedly diminished. Simultaneously definite histological changes were observed in the intestinal mucosa. In spite of the decrease in the absolute amount absorbed, t...

Present study aims to assess the effect of Sublethal dose of the commercial formulations of Cypermethrin (insecticide) and Oxyfluorfen (herbicide). Laboratory study was conducted in a natural Soil and Cow Dung in order to measure effect of these chemicals on activities of stress enzymes viz., Glutathione, Catalase (CAT) and LPO/MDA for a period of 90 days. The activity of Glutathione and CAT wa...

This study has revealed significant variation in total ATPase activity after administration of aluminium acetate in different tissues of albino mice. With sublethal dose (3.5 mg/kg body weight) of aluminium acetate, total ATPase activity was decreased in brain (-50.61), liver (-50.69), kidney (-30.74), heart (-64.07), muscle (-51.50) and testis (-65.53) of albino mice. The decrement was enhance...

whereas others divide at least once before death. Cells selected for their capacity to survive prolonged periods of hyperthermia are killed at approximately the same rate during subsequent heat treatments as cells that had not been heated previously. Hyperthermic cell killing is reduced in cells that are heated in the presence of certain compounds that are inhibitors of DNA and protein synthesi...

The present study defines the early response of normal rabbits to the intravenous injection of a single, sublethal dose of endotoxin. Within the first few hours following endotoxin there occurs in the circulating plasma of recipients a decrease in ionized calcium, a threefold increase in the heat-stable, organo-phosphate-resistant esterase level, and a striking increase in the endotoxin-detoxif...

Mice were injected with a sublethal dose of cyclophosphamide (Cy) (300 mg/kg), and the appearance of the capacity of the regenerating spleen to form cytotoxic T lymphocytes (CTL) in response against 2,4,6 trinitrophenyl-coupled syngeneic cells or against allogeneic cells was followed. It was found that 8 da after Cy injection, the spleen contained cells that could give rise to CTL, but only 2,4...