was good. The wound was cleaned with antiseptic lotions and ether, and the edges which were widely apart were stitched together. Anti-tetanic serum, 1,500 international units, was injected. He was put on an alkaline mixture and sulphonamide tablets (septanilam 0.5 gramme) 6 a day divided in 3 doses. An injection of morphia grain 1/6 with atropine grain 1/200 was also given to relieve the pain. ...

IN an investigation of the function of the enzyme carbonic anhydrase in the formation of the aqueous humour (Langham, 1958b), studies were made with a new carbonic anhydrase inhibitor, 5-acetylimino-4-methyl-A2-1, 3, 4thiadiazoline-2-sulphonamide (Neptazane, Lederle Laboratories). The results of this study indicated that Neptazane was more active than the wellknown carbonic anhydrase inhibitor ...

for prompt treatment of sore throats or recurrences of limb or joint pains and on the importance of penicillin cover for dental extractions if heart lesions persist. If sulphonamide prophylaxis has been started in hospital it should be continued for at least another two years. Patients should attend after-care clinics at regular intervals. Our own are seen at the third, sixth and twelfth month ...

OBJECTIVES In most existing antimicrobial resistance monitoring programmes, one single bacterial colony from each collected sample is susceptibility tested against a panel of antimicrobials. Detecting the proportion of colonies resistant to different antimicrobials in each sample can provide quantitative data on antimicrobial resistance (resistance prevalence per sample). METHODS In this stud...

UNLABELLED Infections caused by bacterial species are common in immunocompromised patients and carry significant treatment costs and mortality. The emerging resistance of microorganisms to some synthetic antimicrobial agents makes it necessary to continue the research for new antimicrobial drugs. AIM To design new sulphonamide compounds with potential antibacterial and antioxidant activity. ...

In December 1944, penicillin was made available to the hospital by the surgeongeneral with the Government of Madras for clinical trial, and since March 1945, it has been purchased in the open market. The following report relates to the results and experience gained in the use of penicillin in the treatment of selected cases of infection which were sulphonamide-resistant, andcaused by organisms ...

Abstract: A selected series of substituted sulphonamides were synthesized. These compounds were tested for potential antitumor activity against three of human tumor cell lines, Liver carcinoma cell line [HEPG2], Brain tumor cell line [U251] and Colon carcinoma cell line [HCT116]. Cytotoxic activity was assessed by SRB assay. The structures of the resulting compounds have been investigated by el...

1. The extent of biliary excretion in the rat of 15 sulphonamide compounds was studied. 2. Most of the sulphonamides studied, with molecular weights from 172 (sulphanilamide) to 352 (N4-acetylsulphadimethoxine) are poorly excreted in the bile (0-4% of the dose), except sulphapyridine, sulphamethoxypyridazine and sulphadimethoxine. The last three are partly metabolized to glucuronides, whose mol...

BACKGROUND Assessment of resistance genes is imperative, as they become disseminated to bacterial flora in plants and to the indigenous bacterial community, and thus ultimately contributes to the clinical problems of antibiotic resistant pathogens. OBJECTIVES The research was to assess the antibiotic characteristics and incidence of sul3 genes of Stenotrophomonas maltophilia isolates recovere...