Aim To create an irreversible pulpitis gene signature from microarray data of healthy and inflamed dental pulps, followed by a bioinformatics approach using connectivity mapping to identify therapeutic compounds that could potentially treat pulpitis. Methodology The Gene Expression Omnibus (GEO) database, international public repository genomics sets, was searched for human datasets assessing A...

introduction: root canal preparation techniques may cause postoperative pain. the aim of the present study was to compare the intensity of postoperative pain after endodontic treatment using hand files, single file rotary (oneshape), and single file reciprocating (reciproc) systems. methods and materials: in this single-blind, parallel-grouped randomized clinical trial a total of 150 healthy pa...

objectives: pain is an unpleasant outcome of endodontic treatment that can be unbearable to patients. instrumentation techniques may affect the frequency and intensity of post-endodontic pain. this study aimed to compare single visit post endodontic pain using mtwo (niti) rotary and hand k-file instruments. materials and methods: in this randomized controlled trial, 60 teeth with symptomatic ir...

INTRODUCTION Post endodontic pain is often linked to the inflammatory process as well as additional central mechanisms. The purpose of the present double-blind randomized clinical trial study was to compare the prophylactic effects of a derivative of Zingiber Officinale, Zintoma, and Ibuprofen on post endodontic pain of molars with irreversible pulpitis. MATERIALS AND METHODS The post endodon...

Pain management after root canal treatment is a very important issue in clinical practice. The purpose of this study was to evaluate the effect of occlusal reduction on postoperative pain in teeth with irreversible pulpitis and tenderness to percussion. This was a prospective, randomized study conducted in Operative Department of dental section of Bahria Dental College and Hospital from June 20...

Background: B-cell activating factor belonging to the TNF family (BAFF) levels may increase in response to oral infections. The aim of the study was to evaluate saliva and serum BAFF levels in patients with oral infection and to monitor them after dental treatments. Materials and methods: Fifteen patients with an oral infection foci including pericoronitis (n = 7) and irreversible pulpitis (n =...

AIM To analyse the gene expression of tumour necrosis factor-alpha (TNF-alpha) in human dental pulps, under normal and inflammatory conditions and to examine the association between any observed alterations in the expression of this cytokine with the severity of the clinical symptoms. METHODOLOGY Eighteen pulpal samples were obtained from single-rooted human teeth. Six of the teeth were norma...

INTRODUCTION Pain management after root canal treatment is a very important issue in clinical practice. The purpose of this study was to evaluate the effect of occlusal reduction on postoperative pain in teeth with irreversible pulpitis and tenderness to percussion. METHODS Fifty-four posterior vital teeth with sensitivity to percussion requiring endodontic treatment were included in this stu...